SML0583
Ferrostatin-1
≥95% (HPLC), powder, non-apoptotic cell death inhibitor
Synonym(s):
3-Amino-4-cyclohexylaminobenzoic acid ethyl ester;
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About This Item
Empirical Formula (Hill Notation):
C15H22N2O2
CAS Number:
Molecular Weight:
262.35
UNSPSC Code:
12352200
NACRES:
NA.77
Product Name
Ferrostatin-1, ≥95% (HPLC)
Quality Level
Assay
≥95% (HPLC)
form
powder
color
, faint purple to brown
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
N(C2CCCCC2)c1c(cc(cc1)C(=O)OCC)N
InChI
1S/C15H22N2O2/c1-2-19-15(18)11-8-9-14(13(16)10-11)17-12-6-4-3-5-7-12/h8-10,12,17H,2-7,16H2,1H3
InChI key
UJHBVMHOBZBWMX-UHFFFAOYSA-N
Related Categories
Application
Ferrostatin-1 has been used to determine its inhibitory effect on the cell death profiles.
Biochem/physiol Actions
Ferrostatin-1 is a potent inhibitor of non-apoptotic cell death induced by erastin call ferroptosis.
Ferrostatin-1 is a potent inhibitor of non-apoptotic cell death induced by erastin call ferroptosis. Ferrostatin-1 prevents ferroptopic cell death in cancer cells and glutamate-induced toxicity in organotypic rat brain slices. It appears that Ferrostatin-1 controls lipid soluble ROS.
Ferrostatin-1 is an active radical-trapping antioxidant that traps peroxyl radicals, and thus serves as a potential inhibitor of ferroptosis. Ferroptosis is considered as regulated necrosis, which differs from apoptosis and autophagy. Ferrostatin-1 is known to show protective effects against Huntington′s disease and also prevents neurotoxicity induced by glutamate in cellular models.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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The neuroprotective role of ferrostatin-1 under rotenone-induced oxidative stress in dopaminergic neuroblastoma cells.
Kabiraj P, et al.
The Protein Journal, 34(5), 349-358 (2015)
On the mechanism of cytoprotection by ferrostatin-1 and liproxstatin-1 and the role of lipid peroxidation in ferroptotic cell death.
Zilka O, et al.
ACS central science, 3(3), 232-243 (2017)
Salinomycin kills cancer stem cells by sequestering iron in lysosomes.
Mai T T, et al.
Nature Chemistry, 9(10), 1025-1025 (2017)
Miao Sui et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 106, 125-133 (2018-06-30)
Ferroptosis is recently reported as a new mode of regulated cell death. It is triggered by disturbed redox homeostasis, overloaded iron and increased lipid peroxidation. Howerver, the role of ferroptosis in hepatic fibrosis remains obscure. In the current study, we
Yimeng Xia et al.
Frontiers in molecular neuroscience, 11, 486-486 (2019-01-29)
The underlying mechanisms of isoflurane neurotoxicity in the developing brain remain unclear. Ferroptosis is a recently characterized form of programmed cell death distinct from apoptosis or autophagy, characterized by iron-dependent reactive oxygen species (ROS) generation secondary to failure of glutathione-dependent
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