SML0586
Lomeguatrib
≥98% (HPLC)
Synonym(s):
2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine, O6-(4-bromothenyl)guanine
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About This Item
Empirical Formula (Hill Notation):
C10H8BrN5OS
CAS Number:
Molecular Weight:
326.17
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
room temp
SMILES string
Nc1nc(OCc2cc(Br)cs2)c3nc[nH]c3n1
InChI
1S/C10H8BrN5OS/c11-5-1-6(18-3-5)2-17-9-7-8(14-4-13-7)15-10(12)16-9/h1,3-4H,2H2,(H3,12,13,14,15,16)
InChI key
JUJPKFNFCWJBCX-UHFFFAOYSA-N
Biochem/physiol Actions
Lomeguatrib is a highly potent inactivator of O(6)-methylguanine-DNA methyltransferase (MGMT), a DNA repair protein which can confer resistance to some cancer chemotherapeutics, in particular the DNA alkylating agents such as Temozolomide, DTIC, Carmustine, etc. Lomeguatrib is a highly potent inactivator of MGMT and can be used to further investigate mechanisms of resistance. It is a potent irreversible inactivator of all mammalian O6-alkylguanine-DNA-alkyltransferases, so far tested with nanomolar activity in vitro and in vivo.
Lomeguatrib is a highly potent irreversible inactivator of O(6)-methylguanine-DNA methyltransferase (MGMT).
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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