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SML0594

CGP 55845 hydrochloride

Name: CGP 55845 hydrochloride
Brand: SIGMA

≥98% (HPLC), GABA-B receptor antagonist, powder

Synonym(s):

(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydro xypropyl](phenylmethyl)phosphinic acid hydrochloride, CGP 55845A, CGP55845

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₂₂Cl₂NO₃P · HCl

CAS Number:

149184-22-5

Molecular Weight:

438.71

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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Product Name

CGP 55845 hydrochloride, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

room temp

SMILES string

[P](=O)(O)(C[C@@H](O)CN[C@@H](C)c2cc(c(cc2)Cl)Cl)Cc1ccccc1

InChI

1S/C18H22Cl2NO3P/c1-13(15-7-8-17(19)18(20)9-15)21-10-16(22)12-25(23,24)11-14-5-3-2-4-6-14/h2-9,13,16,21-22H,10-12H2,1H3,(H,23,24)/t13-,16-/m0/s1

InChI key

ZODSPDOOCZZEIM-BBRMVZONSA-N

Related Categories

Bioactive Small Molecules

Biochem/physiol Actions

CGP 55845 is a potent selective GABA-B receptor antagonist with an IC₅₀of 5 nM.

CGP 55845 is a potent selective GABA-B receptor antagonist..

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAB Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000475290

0000463860

0000463859

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Ovarian hormone deficiency reduces intrinsic excitability and abolishes acute estrogen sensitivity in hippocampal CA1 pyramidal neurons.

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Premature and uncompensated loss of ovarian hormones following ovariectomy (OVX) elevates the risks of cognitive impairment and dementia. These risks are prevented with estrogen (E(2))-containing hormone replacement therapy initiated shortly following OVX but not after substantial delay. Currently, the cellular

Glissandi: transient fast electrocorticographic oscillations of steadily increasing frequency, explained by temporally increasing gap junction conductance.

Mark O Cunningham et al.

Epilepsia, 53(7), 1205-1214 (2012-06-13)

We describe a form of very fast oscillation (VFO) in patient electrocorticography (ECoG) recordings, that can occur prior to ictal events, in which the frequency increases steadily from ≈ 30-40 to >120 Hz, over a period of seconds. We dub

Effects of GABAB ligands alone and in combination with paroxetine on hippocampal BDNF gene expression.

Ahmad A Khundakar et al.

European journal of pharmacology, 671(1-3), 33-38 (2011-09-21)

Brain-derived neurotrophic factor (BDNF) has been suggested as a target for antidepressant treatment and chronic antidepressant drug administration shows a 'biphasic effect' on BDNF mRNA in rat hippocampus (transient decrease followed by an increase). In comparison, following acute administration only

Slow AMPA receptors in hippocampal principal cells.

Niccolò P Pampaloni et al.

Cell reports, 36(5), 109496-109496 (2021-08-05)

Glutamate receptor ion channels, including α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, mediate fast excitatory neurotransmission in the CNS. Previous work suggested that AMPA receptors produce a synaptic current with a millisecond duration. However, we find that about two-thirds of principal cells in

Hyperpolarization induces a long-term increase in the spontaneous firing rate of cerebellar Golgi cells.

Court A Hull et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(14), 5895-5902 (2013-04-05)

Golgi cells (GoCs) are inhibitory interneurons that influence the cerebellar cortical response to sensory input by regulating the excitability of the granule cell layer. While GoC inhibition is essential for normal motor coordination, little is known about the circuit dynamics

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Global Trade Item Number

SKU	GTIN
SML0594-5MG	04061837100543
SML0594-25MG	04061832076072

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