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Merck
CN

SML0602

Propiverine hydrochloride

≥98% (HPLC)

Synonym(s):

α,α-Diphenyl-α-propoxyacetic acid hydrochloride 1-methyl-4-piperidyl ester, α-Phenyl-α-propoxybenzeneacetic acid 1-methyl-4-piperidinyl ester hydrochloride, (1-Methylpiperidin-1-ium-4-yl) 2,2-diphenyl-2-propoxyacetate chloride, 1-Methyl-4-piperidyl diphenylpropoxyacetate hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C23H29NO3 · HCl
CAS Number:
54556-98-8
Molecular Weight:
403.94
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

Propiverine hydrochloride, ≥98% (HPLC)

SMILES string

[Cl-].[N+H]1(CCC(CC1)OC(=O)C(OCCC)(c3ccccc3)c2ccccc2)C

InChI

1S/C23H29NO3.ClH/c1-3-18-26-23(19-10-6-4-7-11-19,20-12-8-5-9-13-20)22(25)27-21-14-16-24(2)17-15-21;/h4-13,21H,3,14-18H2,1-2H3;1H

InChI key

KFUJMHHNLGCTIJ-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Propiverine is an antimuscarinic drug used for the treatment of overactive blaqdder and urinary incontinence. Propiverine and/or its metabolites also have calcium channel blocking properties in addition to antimuscarinic activity, which may contribute to the clinical activity.
Propiverine is an antimuscarinic drug used for the treatment of overactive blaqdder and urinary incontinence.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

General description

Propiverine hydrochloride drug is a tertiary amine with spasmolytic and analgesic properties. This drug exerts neurotropic and musculotropic effects on the urinary bladder and smooth muscles. Propiverine hydrochloride has a half-life of 20 hours.

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000209594
0000209594
0000194807
0000114362
0000112217

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Editorial comment from Dr Sekido to propiverine hydrochloride in Japanese patients with overactive bladder: a randomized, double-blind, placebo-controlled trial.
Noritoshi Sekido
International journal of urology : official journal of the Japanese Urological Association, 18(5), 373-374 (2011-03-09)
Werner Siegmund et al.
Journal of clinical pharmacology, 52(5), 681-690 (2011-05-10)
The muscarinic receptor antagonist propiverine is unique insofar as extended-release (ER) tablets are of higher bioavailability than immediate-release (IR) tablets; this is caused by lower "first-pass" elimination of propiverine via CYP3A4 and efflux transporters in the distal small intestine and
Daniela Schultz-Lampel et al.
Deutsches Arzteblatt international, 108(37), 613-620 (2011-10-07)
Urinary incontinence (bedwetting, enuresis) is the commonest urinary symptom in children and adolescents and can lead to major distress for the affected children and their parents. Physiological and non-physiological types of urinary incontinence are sometimes hard to tell apart in
Editorial comment from Dr Dmochowski to propiverine hydrochloride in Japanese patients with overactive bladder: a randomized, double-blind, placebo-controlled trial.
Roger R Dmochowski
International journal of urology : official journal of the Japanese Urological Association, 18(5), 374-374 (2011-03-02)
Tetsuo Ogata et al.
Chemical & pharmaceutical bulletin, 60(8), 976-984 (2012-08-07)
The aim of the present study was to mask the bitterness of propiverine hydrochloride (P-4) by converting it to propiverine free base. Fine granules comprising the free base, which was converted from P-4 by desalination, were prepared. By using Fourier
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Articles

Muscarinic Acetylcholine Receptors

Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.

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