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About This Item
Empirical Formula (Hill Notation):
C122H196N40O39 · xC2HF3O2
Molecular Weight:
2847.11 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
Assay
≥95% (HPLC)
form
powder
color
white to off-white
shipped in
wet ice
storage temp.
−20°C
Amino Acid Sequence
Ac-Leu-Gly-Arg-Leu-Ser-Gln-Glu-Leu-His-Arg-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2
Biochem/physiol Actions
AC253 is an antagonist of Amylin, one of the peptides in the Calcitonin-gene related peptide (CGRP) family. In recent studies. AC253 restored memories in brain cells taken from animals used as models of Alzheimer′s disease. Application of AC253 significantly enhanced long-term potentiation (LTP) when given to 6- to 12-month-old TgCRND8 mice that normally show blunted LTP. In other studies, AC25 neutralized the depressant effects of Aβ(1-42) on hippocampal LTP without affecting baseline transmission or LTP on its own.
AC253 is an antagonist of Amylin.
Features and Benefits
This compound is featured on the Calcitonin Gene-Related Peptides page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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