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SML0634

CID2858522

≥98% (HPLC)

Synonym(s):

1-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-[2-[(3-hydroxypropyl)amino]-5,6-dimethyl-1H-benzimidazol-1-yl]-ethanone

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About This Item

Empirical Formula (Hill Notation):
C28H39N3O3
CAS Number:
758679-97-9
Molecular Weight:
465.63
NACRES:
NA.77
PubChem Substance ID:
329825572
UNSPSC Code:
12352200
MDL number:
MFCD20755108
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

Cc1cc2nc(NCCCO)n(CC(=O)c3cc(c(O)c(c3)C(C)(C)C)C(C)(C)C)c2cc1C

InChI

1S/C28H39N3O3/c1-17-12-22-23(13-18(17)2)31(26(30-22)29-10-9-11-32)16-24(33)19-14-20(27(3,4)5)25(34)21(15-19)28(6,7)8/h12-15,32,34H,9-11,16H2,1-8H3,(H,29,30)

InChI key

CYCGGKILBWERDJ-UHFFFAOYSA-N

Biochem/physiol Actions

CID2858522 specifically inhibits NF-kB activation downstream of protein kinsase C (PKC).
CID2858522 specifically inhibits NF-kB activation downstream of protein kinsase C (PKC). CID2858522 dose dependently inhibits NF-kB reporter activity in PMA-ionomycin stimulated HEK293 cells, but does not affect NF-kB activity in cells challenged with TNFa, retinoic acid, or stimulation of the toll-like receptor signaling pathway.

Storage Class

11 - Combustible Solids

wgk

WGK 3

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