SML0664
LM11A-31 dihydrochloride
≥95% (HPLC)
Synonym(s):
2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]-pentanamide dihydrochloride
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About This Item
Empirical Formula (Hill Notation):
C12H25N3O2 · 2HCl
CAS Number:
Molecular Weight:
316.27
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Assay:
≥95% (HPLC)
Form:
oil
Storage condition:
desiccated
Quality Segment
assay
≥95% (HPLC)
form
oil
storage condition
desiccated
color
colorless to yellow
storage temp.
2-8°C
SMILES string
Cl.Cl.CCC(C)C(N)C(=O)NCCN1CCOCC1
InChI
1S/C12H25N3O2.2ClH/c1-3-10(2)11(13)12(16)14-4-5-15-6-8-17-9-7-15;;/h10-11H,3-9,13H2,1-2H3,(H,14,16);2*1H
InChI key
LLIHJRRZJDEKLB-UHFFFAOYSA-N
Application
LM11A-31 dihydrochloride has been used to study the effect of p75 neurotrophin receptor (p75 NTR) blockade, by non-peptide LM11A-31 ligand, on PC12 cell viability.
Biochem/physiol Actions
LM11A-31 is a non-peptide ligand of the p75 neurotrophin receptor (p75NTR). LM11A-31 blocks pro-NGF induced cell death in neuronal cultures, and protects neuronal cells from the the cytotoxic effects of cisplatin or methotrexate. Oral administration of LM11A-31 promotes the survival of oligodendrocytes and myelinated axons in a mouse spinal cord injury model and improves function in both weight-bearing and non-weight bearing tests.
LM11A-31 is a p75 neurotrophin receptor (p75NTR) ligand.
signalword
Warning
hcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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