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Merck
CN

SML0674

Ramosetron hydrochloride

≥98% (HPLC), 5-HT3 receptor antagonist, powder

Synonym(s):

(R)-5-[(1-Methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydro-1H-benzimidazole hydrochloride, YM-060, YM060

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About This Item

Empirical Formula (Hill Notation):
C17H17N3O · HCl
CAS Number:
132907-72-3
Molecular Weight:
315.80
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

Ramosetron hydrochloride, ≥98% (HPLC)

SMILES string

Cl.[n]1(c2c(c(c1)C(=O)[C@@H]3CCc4nc[nH]c4C3)cccc2)C

InChI

1S/C17H17N3O.ClH/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14;/h2-5,9-11H,6-8H2,1H3,(H,18,19);1H/t11-;/m1./s1

InChI key

XIXYTCLDXQRHJO-RFVHGSKJSA-N

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -36 to -46°, c = 1 in methanol

storage condition

desiccated

color

white to beige

solubility

H2O: 20 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Ramosetron hydrochloride is a potent serotonin 5-HT3 receptor antagonist with higher afinity for the 5-HT3 receptor than other currently available antagonists.
Ramosetron hydrochloride is a potent serotonin 5-HT3 receptor antagonist with higher afinity for the 5-HT3 receptor than other currently available antagonists. Ramosetron is used clinically both as an antiemetic to treat nausea and vomiting following chemotherapy or after surgery, and in treatment of irritable bowel syndrome.
Ramosetron is a tetra hydrobenzimidazole derivative, containing an indole ring. It inhibits colon contraction mediated by serotonin, competitively.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000266264
0000370844
0000370844
0000266264
0000247049

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Matching groups for studying postoperative nausea and vomiting: should we care?
Boris Mraovic et al.
Surgical endoscopy, 24(7), 1796-1797 (2010-01-02)
Youn Yi Jo et al.
Surgical endoscopy, 26(8), 2306-2311 (2012-02-24)
In this randomized and controlled study, we evaluated the antiemetic efficacy of ramosetron combined with dexamethasone for postoperative nausea and vomiting (PONV) compared with that of dexamethasone or ramosetron alone in women who underwent laparoscopic cholecystectomy. One hundred twenty female
Takahiro Mihara et al.
Anesthesia and analgesia, 117(2), 329-339 (2013-06-13)
Ramosetron has been shown to have a very strong effect for preventing postoperative nausea and vomiting (PONV) in previous meta-analyses. However, these previous meta-analyses included a number of studies by Fujii et al. which have now been proven to have
Ramosetron might be useful for treating diabetic diarrhea with a rapid small bowel transit time.
Tae Hee Lee et al.
The Korean journal of internal medicine, 28(1), 106-107 (2013-01-25)
Maulana M Ansari et al.
Indian journal of medical sciences, 64(6), 272-280 (2010-06-01)
Post-operative nausea and vomiting (PONV) is common. 5HT 3 receptor antagonists are commonly used drugs for its prevention. A study was designed to compare the efficacy and safety of ramosetron and ondansetron in patients undergoing laparoscopic cholecystectomy (lap chole). A
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