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SML0674

Sigma-Aldrich

Ramosetron hydrochloride

≥98% (HPLC)

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Synonym(s):
(R)-5-[(1-Methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydro-1H-benzimidazole hydrochloride, YM-060, YM060
Empirical Formula (Hill Notation):
C17H17N3O · HCl
CAS Number:
132907-72-3
Molecular Weight:
315.80
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -40 to -45°, c = 1 in methanol

storage condition

desiccated

color

white to beige

solubility

H2O: 20 mg/mL, clear

storage temp.

−20°C

InChI

1S/C17H17N3O.ClH/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14;/h2-5,9-11H,6-8H2,1H3,(H,18,19);1H/t11-;/m1./s1

InChI key

XIXYTCLDXQRHJO-RFVHGSKJSA-N

Biochem/physiol Actions

Ramosetron hydrochloride is a potent serotonin 5-HT3 receptor antagonist with higher afinity for the 5-HT3 receptor than other currently available antagonists. Ramosetron is used clinically both as an antiemetic to treat nausea and vomiting following chemotherapy or after surgery, and in treatment of irritable bowel syndrome.
Ramosetron is a tetra hydrobenzimidazole derivative, containing an indole ring. It inhibits colon contraction mediated by serotonin, competitively.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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A new antiemetic ramosetron hydrochloride
Tsukagoshi S
Gan to Kagaku Ryoho. Cancer & Chemotherapy, 24(3), 371-380 (2016)
Yoshitaka Fujii
Current drug safety, 6(2), 122-127 (2011-03-09)
Postoperative nausea and vomiting (PONV) are distressing and frequent adverse events of anesthesia and surgery. Serotonin receptor antagonists (SRAs), including ondansetron, granisetron, tropisetron, dolasetron, and ramosetron, effectively decrease the incidence of PONV. Among these SRAs, ramosetron is the most effective
Hyo-Jin Byon et al.
European journal of anaesthesiology, 29(4), 192-196 (2012-01-26)
Postoperative nausea and vomiting remains a clinically important problem after strabismus surgery in children. To study the benefit of adding midazolam to ramosetron on the incidence of postoperative nausea, retching or vomiting and on the incidence of postoperative agitation. A
Jung-Hee Ryu et al.
International journal of surgery (London, England), 11(2), 183-187 (2013-01-15)
Up to 75% of the patients undergoing laparoscopic cholecystectomy develop postoperative nausea and vomiting (PONV). Both ramosetron, a serotonin subtype 3 (5-HT3) antagonist, and dexamethasone are effective for PONV prophylaxis following laparoscopic cholecystectomy but their combined effect has not been
In Jun Koh et al.
Clinical orthopaedics and related research, 470(6), 1718-1727 (2011-12-14)
Current pain management protocols involving many anesthetic and analgesic drugs reportedly provide adequate analgesia after TKA. However, control of emetic events associated with the drugs used in current multimodal pain management remains challenging. We determined (1) whether ramosetron prophylaxis reduces
View All Related Papers

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