CYM-5541

Name: CYM-5541
Brand: SIGMA

≥98% (HPLC)

Synonym(s):

CYM5541, ML249, N,N-Dicyclohexyl(5-cyclopropylisoxazol-3-yl)-carboxamide, N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₂₈N₂O₂

CAS Number:

945128-26-7

Molecular Weight:

316.44

UNSPSC Code:

12352211

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

N(C4CCCCC4)(C3CCCCC3)C(=O)c1n[o]c(c1)C2CC2

InChI

1S/C19H28N2O2/c22-19(17-13-18(23-20-17)14-11-12-14)21(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h13-16H,1-12H2

InChI key

NDKGACIWVAOUQH-UHFFFAOYSA-N

Description

Biochem/physiol Actions

CYM-5541 is an allosteric agonist selective for the Sphingosine 1-phosphate (S1P) S1P3 receptor subtype. CYM-5541 occupies a different chemical space in the ligand binding pocket of S1P3 than S1P does, a lower hydrophobic region around transmembrane helix TM6. CYM-5541 shows great selectivity and stability with an EC₅₀ of between 72 and 132 nM compared to S1P1 EC₅₀ > 10 μM, S1P2 EC₅₀> 50 μM, S1P4 EC₅₀ > 50 μM, and S1P5 EC₅₀ > 25 μM and no significant activities for a panel of 55 GPCRs, ion channels, and transporters.

CYM-5541 is an allosteric agonist selective for the Sphingosine 1-phosphate (S1P) S1P3 receptor subtype.

Features and Benefits

This compound is featured on the Lysophospholipid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.