SML0681
Febrifugine dihydrochloride
≥95% (HPLC)
Synonym(s):
3-[3-[(2R,3S)-3-Hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone dihydrochloride
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About This Item
Empirical Formula (Hill Notation):
C16H19N3O3 · 2HCl
CAS Number:
Molecular Weight:
374.26
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥95% (HPLC)
form
powder
optical activity
[α]/D 10 to 15°, c = 1 in H2O
storage condition
desiccated
color
off-white to gray-brown
solubility
H2O: 15 mg/mL, clear
storage temp.
−20°C
SMILES string
O=C1C2=CC=CC=C2N=CN1CC(C[C@@H]3[C@@H](O)CCCC3)=O.C
InChI
1S/C17H20N2O3.CH4/c20-13(9-12-5-1-4-8-16(12)21)10-19-11-18-15-7-3-2-6-14(15)17(19)22;/h2-3,6-7,11-12,16,21H,1,4-5,8-10H2;1H4/t12-,16+;/m1./s1
InChI key
SNTOTCUGCWLHEZ-KKJWGQAZSA-N
Biochem/physiol Actions
Febrifugine dihydrochloride exhibits strong antimalarial activity against Plasmodium falciparum, the most insidious malaria causative agent. The adverse effects of febrifugine include diarrhoea, vomiting and liver toxicity.
Febrifugine is an antimalarial, the active component of the Chinese herb Chang Shan. Recent studies indicate that its mechanism of action is as an inhibitor of prolyl-transfer RNA synthetase (ProRS).
Febrifugine is an antimalarial, the active component of the Chinese herb Chang Shan; inhibitor of prolyl-transfer RNA synthetase (ProRS).
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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