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SML0681

Febrifugine dihydrochloride

≥95% (HPLC)

Synonym(s):

3-[3-[(2R,3S)-3-Hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C16H19N3O3 · 2HCl
CAS Number:
32434-42-7
Molecular Weight:
374.26
UNSPSC Code:
51111800
PubChem Substance ID:
329825583
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated
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Quality Level

100

assay

≥95% (HPLC)

form

powder

optical activity

[α]/D 10 to 15°, c = 1 in H2O

storage condition

desiccated

color

off-white to gray-brown

solubility

H2O: 15 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C1C2=CC=CC=C2N=CN1CC(C[C@@H]3[C@@H](O)CCCC3)=O.C

InChI

1S/C17H20N2O3.CH4/c20-13(9-12-5-1-4-8-16(12)21)10-19-11-18-15-7-3-2-6-14(15)17(19)22;/h2-3,6-7,11-12,16,21H,1,4-5,8-10H2;1H4/t12-,16+;/m1./s1

InChI key

SNTOTCUGCWLHEZ-KKJWGQAZSA-N

Related Categories

Biochem/physiol Actions

Febrifugine dihydrochloride exhibits strong antimalarial activity against Plasmodium falciparum, the most insidious malaria causative agent. The adverse effects of febrifugine include diarrhoea, vomiting and liver toxicity.
Febrifugine is an antimalarial, the active component of the Chinese herb Chang Shan. Recent studies indicate that its mechanism of action is as an inhibitor of prolyl-transfer RNA synthetase (ProRS).
Febrifugine is an antimalarial, the active component of the Chinese herb Chang Shan; inhibitor of prolyl-transfer RNA synthetase (ProRS).

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000445612
0000445612
0000241532
0000241532
0000166697

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The chemistry and biology of febrifugine and halofuginone.
McLaughlin N P, et al.
Bioorganic & Medicinal Chemistry, 22(7), 1993-2004 (2014)

Articles

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

Global Trade Item Number

SKUGTIN
SML0681-25MG04061832634340
SML0681-5MG04061832634357

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