Skip to Content
Merck
CN

SML0693

LY-333531 hydrochloride

≥98% (HPLC)

Synonym(s):

(9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-Dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione hydrochloride, Ruboxistaurin

Sign In to View Organizational & Contract Pricing

Select a Size

About This Item

Empirical Formula (Hill Notation):
C28H28N4O3 · HCl
CAS Number:
169939-93-9
Molecular Weight:
505.01
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated
protect from light

color

orange-red

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

Cl.[n]21c3c(c(c2)C4=C(c5c6c([n](c5)CC[C@H](OCC1)CN(C)C)cccc6)C(=O)NC4=O)cccc3

InChI

1S/C28H28N4O3.ClH/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24;/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34);1H/t18-;/m0./s1

InChI key

NYQIEYDJYFVLPO-FERBBOLQSA-N

Related Categories

General description

LY-333531 hydrochloride is also known as ruboxistaurin.

Application

LY-333531 hydrochloride/ruboxistaurin has been used as a PKCB blocker to compare phosphopeptides derived from stimulated wild-type cells to phosphopeptides derived from either PKCB knockout cells or wild-type cells.

Biochem/physiol Actions

LY333531 is a potent inhibitor of protein kinase Cβ (PKCβ; 4.7 and 5.9 nM IC50 values for PKCβ1 and PKCβ2, respectively). PKCβ isoforms are overexpressed in states of oxidative stress, especially in association with diabetes. In diabetic rats, LY333531 improves blood flow and leukocyte entrapment in the retina, and protects against myocardial hypertrophy and cardiac dysfunction.
LY333531 is a potent, specific inhibitor of PKCβ.

Features and Benefits

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

Light sensitive

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
066M4705V
075M4708V
043M4746V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Protein Kinase C β: a New Target Therapy to Prevent the Long-Term Atypical Antipsychotic-Induced Weight Gain.
Rimessi A, et al.
Neuropsychopharmacology, 42(7), 1491?1501-1491?1501 (2017)
Phosphorylation of residues inside the SNARE complex suppresses secretory vesicle fusion.
Malmersjo S, et al.
The Embo Journal, e201694071-e201694071 (2016)
Hongwei Yi et al.
Antioxidants & redox signaling, 30(17), 1949-1968 (2018-11-30)
Aims: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver diseases. However, there are no approved pharmacotherapies for the treatment of NAFLD other than managing life style and controlling diets. Extensive studies have demonstrated that multiple
Ping Jiang et al.
Clinical and experimental pharmacology & physiology, 44(7), 760-770 (2017-04-11)
Tiron functions as an effective antioxidant alleviating the intracellular reactive oxygen species (ROS) or the acute toxic metal overload. Previous studies have shown that cardiac myocyte apoptosis can be effectively inhibited by tiron administration in streptozotocin (STZ)-induced diabetic rats, primary
Mehdi Bouhaddou et al.
Cell, 182(3), 685-712 (2020-07-10)
The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed hundreds of thousands of people worldwide, highlighting an urgent need to develop antiviral therapies. Here we present a

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service