SML0716
SB225002
≥98% (HPLC), chemokine receptor CXCR2 inhibitor, powder
Synonym(s):
N-(2-Hydroxy-4-nitrophenyl)-N′-(2-bromophenyl)urea, SB-225002
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About This Item
Empirical Formula (Hill Notation):
C13H10BrN3O4
CAS Number:
Molecular Weight:
352.14
UNSPSC Code:
51111800
NACRES:
NA.77
Product Name
SB225002, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
room temp
SMILES string
Brc1c(cccc1)NC(=O)Nc2c(cc(cc2)[N+](=O)[O-])O
InChI
1S/C13H10BrN3O4/c14-9-3-1-2-4-10(9)15-13(19)16-11-6-5-8(17(20)21)7-12(11)18/h1-7,18H,(H2,15,16,19)
InChI key
MQBZVUNNWUIPMK-UHFFFAOYSA-N
Biochem/physiol Actions
Blocking action of SB-225002 on CXCR2 (interleukin 8 receptor β), prevents the IL-8 induced matrix metalloproteinase-9 release from neutrophils. Matrix metalloproteinase-9 are proteolytic enzymes associated with inflammation.
SB-225002 is a potent nonpeptide inhibitor of chemokine receptor CXCR2 with an IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2 and > 150-fold selectivity over CXCR1 receptors. CXCR2 binds many different immune cell chemoattractants. SB-225002 is crucial for cancer progression and is involved in inflammatory diseases like COPD, rheumatoid arthritis, and ulcerative colitis.
SB-225002 is a potent nonpeptide inhibitor of chemokine receptor CXCR2.
Features and Benefits
This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Articles
We offer many products related to chemokine receptors for your research needs.
Regulation of matrix metalloproteinase-9 release from IL-8-stimulated human neutrophils.
Chakrabarti S and Patel K D
Journal of Leukocyte Biology, 78(1), 279-288 (2005)
Dong Cui et al.
Cancer biology & therapy, 20(5), 608-616 (2018-11-09)
C-X-C motif chemokine ligand 5 (CXCL5) is initially identified to recruit neutrophils by interacting with its receptor, C-X-C motif chemokine receptor 2 (CXCR2). Our prior work demonstrated that the expression levels of CXCL5 and CXCR2 were higher in the papillary
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML0716-25MG | 04061833223666 |
| SML0716-5MG | 04061833223673 |