SML0730
PCNA-I1
≥98% (HPLC)
Synonym(s):
N-(3-Methylthiophene-2-carboxylic acid)-N′-[(3-hydroxy-2-naphthalenyl)methylene]hydrazide
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About This Item
Empirical Formula (Hill Notation):
C17H14N2O2S
CAS Number:
Molecular Weight:
310.37
NACRES:
NA.77
UNSPSC Code:
12352200
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
Related Categories
Biochem/physiol Actions
Proliferating cell nuclear antigen-l1 (PCNA) is a member of the scaffold B class. It acts as a linker at the monomer-monomer interface. PCNA-I1 has the ability to block the development of primary cultures of bone marrow mesenchymal stem cells, endothelial cells, lymphocytes, mammary epithelial cells and prostate epithelial cells.
PCNA-I1 is a PCNA inhibitor.
PCNA-I1 is a small molecule PCNA inhibitor that selectively binds to PCNA trimers and reduces the association of PCNA with chromatin. PCNA-I1 induces S and G2/M phase cell cycle arrest in tumor cells with greater efficacy than non-transformed cells.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Target validation and structure-activity analysis of a series of novel PCNA inhibitors
Dillehay KL, et al.
Pharmacology Research & Perspectives, 3(2), e00115-e00115 (2015)
Small molecule targeting of PCNA chromatin association inhibits tumor cell growth
Tan Z, et al.
Molecular Pharmacology, mol-112 (2012)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML0730-5MG | 04061833066577 |
| SML0730-25MG | 04061833066560 |
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