SML0753
PSB-12062
≥98% (HPLC)
Synonym(s):
10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine
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About This Item
Empirical Formula (Hill Notation):
C19H15NO3S
CAS Number:
Molecular Weight:
337.39
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
[S](=O)(=O)(N2c3c(cccc3)Oc4c2cccc4)c1ccc(cc1)C
InChI
1S/C19H15NO3S/c1-14-10-12-15(13-11-14)24(21,22)20-16-6-2-4-8-18(16)23-19-9-5-3-7-17(19)20/h2-13H,1H3
InChI key
DHZNMEIBMACSFH-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
Application
PSB-12062 has been used as a P2X4 antagonist to pre-treat macrophages in inhibitor screening studies to understand the inflammation process. It has also been used as P2X4 antagonists to pre-treat P2X7-deficient BV-2 cells to elucidate the roles of P2X4.
Biochem/physiol Actions
PSB-12062 is a P2X4 receptor antagonist.
PSB-12062 is a P2X4 receptor antagonist. P2X4 receptors are highly expressed in the central nervous system (CNS), and have been studied as a therapeutic target for neutopathic pain, and treatment of traumatic brain injury, cerebral ischemia, and spinal cord injury. PBS-12062 is a new P2X4-specific antagonist with equal potency against human, rat and mouse receptors (IC50s 1.38, 0.92 and 1.76 μM, respecitively). The compound does not display significant inhibition of human P2X1, P2X2, P2X3 or P2X7 at 10 μM.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 4
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Stefan Uderhardt et al.
Cell, 177(3), 541-555 (2019-04-09)
Neutrophils are attracted to and generate dense swarms at sites of cell damage in diverse tissues, often extending the local disruption of organ architecture produced by the initial insult. Whether the inflammatory damage resulting from such neutrophil accumulation is an
Kshitija Dhuna et al.
Molecular pharmacology, 95(2), 210-221 (2018-12-14)
We investigated the selectivity of protopanaxadiol ginsenosides from Panax ginseng acting as positive allosteric modulators on P2X receptors. ATP-induced responses were measured in stable cell lines overexpressing human P2X4 using a YOPRO-1 dye uptake assay, intracellular calcium measurements, and whole-cell
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