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Merck
CN

SML0756

Sigma-Aldrich

IDT307

≥98% (HPLC), DAT, NET and SERT substrate, powder

Synonym(s):

4-(4-Dimethylamino)phenyl-1-methylpyridinium iodide, 4-[p-(Dimethylamino)phenyl]-1-methylpyridinium iodide, APP+

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About This Item

Empirical Formula (Hill Notation):
C14H17N2 · I
CAS Number:
1141-41-9
Molecular Weight:
340.20
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

IDT307, ≥98% (HPLC)

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

, orange to dark orange-red

solubility

DMSO: 15 mg/mL, clear

storage temp.

−20°C

SMILES string

[I-].[n+]1(ccc(cc1)c2ccc(cc2)N(C)C)C

InChI

1S/C14H17N2.HI/c1-15(2)14-6-4-12(5-7-14)13-8-10-16(3)11-9-13;/h4-11H,1-3H3;1H/q+1;/p-1

InChI key

CAMWVBRDIKKGII-UHFFFAOYSA-M

Related Categories

Biochem/physiol Actions

IDT307 (APP+) is a fluorescent analogue of the dopaminergic neurotoxin MPP+ monoamine transporter substrate that fluoresces after uptake into cells. IDT307 is a substrate for the dopamine transporter (DAT), norepinephrine transporter (NET), and serotonin transporter (SERT). IDT307 (APP+) was found to label catecholamine neuronal cell bodies with high selectivity in midbrain and was used to investigate SERT function in lymphocytes and platelets.
IDT307 (APP+) is a fluorescent analogue of the dopaminergic neurotoxin MPP+.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H300

Hazard Classifications

Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000429815
0000429814
0000429815
0000429814
0000425707

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M Engevik et al.
Beneficial microbes, 12(6), 583-599 (2021-09-23)
The serotonin transporter (SERT) readily takes up serotonin (5-HT), thereby regulating the availability of 5-HT within the intestine. In the absence of SERT, 5-HT remains in the interstitial space and has the potential to aberrantly activate the many 5-HT receptors

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