SML0773
GSK-650394
≥98% (HPLC)
Synonym(s):
2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzoic acid, GSK 650394, GSK650394
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About This Item
Empirical Formula (Hill Notation):
C25H22N2O2
CAS Number:
Molecular Weight:
382.45
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
room temp
SMILES string
[nH]1c2ncc(cc2c(c1)c4cc(c(cc4)C(=O)O)C5CCCC5)c3ccccc3
InChI
1S/C25H22N2O2/c28-25(29)20-11-10-18(12-21(20)17-8-4-5-9-17)23-15-27-24-22(23)13-19(14-26-24)16-6-2-1-3-7-16/h1-3,6-7,10-15,17H,4-5,8-9H2,(H,26,27)(H,28,29)
InChI key
WVSBGSNVCDAMCF-UHFFFAOYSA-N
Application
GSK-650394 has been used as a serum and glucocorticoid-activated kinase (SGK1) inhibitor.
Biochem/physiol Actions
GSK-650394 has an IC50 value of 62 nM for serum and glucocorticoid-activated kinase-1 (SGK1) and 103 nM for SGK2. It has an ability to stop viral replication at concentrations that are nontoxic to cells.
GSK-650394 is a potent and selective Serum- and glucocorticoid-regulated kinase 1 (SGK1) antagonist.
GSK-650394 is a potent, selective SGK1 antagonist.
Features and Benefits
This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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