SML0776
Galloflavin
≥95% (HPLC)
Synonym(s):
3,8,9,10-Tetrahydroxy-pyrano[3,2-c][2]benzopyran-2,6-dione, NSC 107022
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About This Item
Empirical Formula (Hill Notation):
C12H5O8
CAS Number:
Molecular Weight:
277.16
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C12H6O8/c13-4-1-3-7(9(16)8(4)15)10-6(19-11(3)17)2-5(14)12(18)20-10/h1-2,13-16H
SMILES string
OC1=C(O)C(O)=CC2=C1C3=C(C=C(O)C(O3)=O)OC2=O
InChI key
VYKVZHXHVUVABA-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
powder
storage condition
desiccated
color
light yellow to light brown
solubility
DMSO: 5 mg/mL, clear
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Galloflavin is an inhibitor of lactate dehydrogenase (LDH).
Galloflavin is an inhibitor of lactate dehydrogenase (LDH). The compound blocks both isoforms of (LDH-A and –B) with Ki values of 5.5 and 15 μM, respectively. Inhibition of the glycolytic pathway by galloflavin induces oxidative stress and apoptosis in breast tumor cell lines.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Simone Kumstel et al.
Scientific reports, 10(1), 16931-16931 (2020-10-11)
Severity assessment of animal experiments is mainly conducted by using subjective parameters. A widely applicable biomarker to assess animal distress could contribute to an objective severity assessment in different animal models. Here, the distress of three murine animal models for
Abd El-Galil E Amr et al.
Molecules (Basel, Switzerland), 25(5) (2020-03-04)
A series of branched tetrapeptide Schiff bases 3-6 were designed and synthesized from corresponding tetrapeptide hydrazide 2 as a starting material.In vitroevaluation of the synthesized compounds 4-6 against breast MCF-7 carcinoma cells identified their excellent anticancer potency, with IC50 ranging
John A G Moir et al.
Pancreas, 49(10), 1364-1371 (2020-10-31)
Pancreatic stellate cells (PSCs) play a key metabolic role within the tumor microenvironment (stroma) of pancreatic ductal adenocarcinoma (PDAC), being glycolytic and associated with protumorigenic acidification from excess lactate. This study investigates the clinical significance of glycolytic enzyme lactate dehydrogenase
Guorong Cheng et al.
Talanta, 209, 120554-120554 (2020-01-02)
Lactate dehydrogenase (LDH), catalyzing the conversion of pyruvate to lactate during glycolysis, is overexpressed in cancer cells. LDH inhibitors are a promising approach for the treatment of cancer. But up till now, there is limited method for rapid screening of
Jilong Zhou et al.
Biology of reproduction, 99(2), 308-318 (2018-03-17)
Autophagy is an essential cellular mechanism that degrades cytoplasmic proteins and organelles to recycle their components. Here we showed that autophagy was essential for the glycolysis switch and energy homeostasis in mouse granulosa cells under hypoxic condition. Our data indicated
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