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Merck
CN

SML0794

T2AA hydrochloride

≥98% (HPLC)

Synonym(s):

(S)-4-(4-(2-amino-3-hydroxypropyl)-2,6-diiodophenoxy)phenol hydrochloride, T2-aminoalcohol hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C15H15I2NO3 · HCl
CAS Number:
1380782-27-3
Molecular Weight:
547.55
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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SMILES string

Ic1c(c(cc(c1)C[C@H](N)CO)I)Oc2ccc(cc2)O

InChI

1S/C15H15I2NO3/c16-13-6-9(5-10(18)8-19)7-14(17)15(13)21-12-3-1-11(20)2-4-12/h1-4,6-7,10,19-20H,5,8,18H2/t10-/m0/s1

InChI key

NKOSKXJRVWVXRI-JTQLQIEISA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Related Categories

Application

T2AA hydrochloride has been used as a chemical inhibitor of proliferating cell nuclear antigen (PCNA) in vaccinia virus.

Biochem/physiol Actions

T2AA is an inhibitor of PCNA/ PIP-Box interactions that binds to the PCNA cavity that interacts with PIP-Box sequences. Also T2AA inhibits PCNA Polδ3 interaction. T2AA inhibits de novo DNA synthesis, and in combination of cisplatin significantly increases growth inhibition in cancer cells. T2AA is a T3 analog that exhibits almost no thyroid hormone activity.
T2AA is an inhibitor of PCNA/ PIP-Box interactions; inhibits PCNA Polδ3 interaction.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000524388
0000524388
0000435749
0000435749
0000391158

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Cytoplasmic ATR activation promotes vaccinia virus genome replication.
Postigo A, et al.
Cell Reports, 19(5), 1022-1032 (2017)

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