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SML0797

Flibanserin

≥98% (HPLC)

Synonym(s):

1,3-Dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-2H-benzimidazol-2-one, BIMT 17, BIMT 17BS

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About This Item

Empirical Formula (Hill Notation):
C20H21F3N4O
CAS Number:
167933-07-5
Molecular Weight:
390.40
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

FC(F)(F)c1ccc(cc1)N2CCN(CC2)CC[n]3c4c([nH][c]3=O)cccc4

InChI

1S/C20H21F3N4O/c21-20(22,23)15-5-7-16(8-6-15)26-12-9-25(10-13-26)11-14-27-18-4-2-1-3-17(18)24-19(27)28/h1-8H,9-14H2,(H,24,28)

InChI key

CCIZQGRSEAHATK-UHFFFAOYSA-N

Biochem/physiol Actions

Flibanserin is a 5-HT1A receptor agonist and 5-HT2A receptor antagonist.
Flibanserin is a 5-HT1A receptor agonist and 5-HT2A receptor antagonist. Flibanserin has high affinity for human 5-HT1A receptors (Ki = 1 nm) and lower affinity for 5-HT2A (Ki = 49 nm) and D4 (Ki = 4–24 nm) receptors, and negligible affinity for a variety of other neurotransmitter receptors and ion channels. Flibanserin was investigated as a novel, non-hormonal treatment for pre-menopausal women with Hypoactive Sexual Desire Disorder (HSDD). Flibanserin. Recently, Flibanserin was found to reduce L-DOPA-induced dyskinesia in a model of Parkinson′s Disease.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000520305
0000520305
0000265373
0000265373
0000487099

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Consultation corner. The latest on female sexual health.
Leonard R DeRogatis
The Johns Hopkins medical letter health after 50, 22(9), 6-7 (2010-11-12)
[The abandonment of the development of flibanserin].
Jean-Yves Nau
Revue medicale suisse, 6(268), 2044-2045 (2010-12-09)
Do drugs have a role in turning indifference into passion?
Nigel Hawkes
BMJ (Clinical research ed.), 341, c5532-c5532 (2010-10-07)
Min-Yong Low et al.
Journal of pharmaceutical and biomedical analysis, 57, 104-108 (2011-10-01)
A health supplement used for female sexual performance enhancement was sent to Health Sciences Authority of Singapore for testing. An unknown compound was detected and isolated from the health supplement and its structure was elucidated using LC-DAD, LC-FTMS, NMR and
[When women complain about lacking libido. The problem with the desire].
Katharina Arnheim
MMW Fortschritte der Medizin, 152(34-35), 12-13 (2010-10-07)
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Articles

DISCOVER Bioactive Small Molecules for Neuroscience

DISCOVER Bioactive Small Molecules for Neuroscience

Global Trade Item Number

SKUGTIN
SML0797-25MG04061832076546
SML0797-5MG04061832076553

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