SML0814
ESI-09
≥98% (HPLC)
Synonym(s):
α-[2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-b-oxo-3-isoxazolepropanenitrile
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About This Item
Empirical Formula (Hill Notation):
C16H15ClN4O2
CAS Number:
Molecular Weight:
330.77
UNSPSC Code:
41106305
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
, faint yellow to dark orange
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
SMILES string
Clc1cc(ccc1)N\N=C(\C(=O)c2n[o]c(c2)C(C)(C)C)/C#N
InChI
1S/C16H15ClN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-5-10(17)7-11/h4-8,19H,1-3H3/b20-13+
InChI key
DXEATJQGQHDURZ-DEDYPNTBSA-N
Application
ESI-09 has been used as an antagonist for exchange factor directly activated by cAMP (EPAC).
Biochem/physiol Actions
ESI-09 is a potent, specific inhibitor of EPAC (exchange protein directly activated by cAMP).
ESI-09 is a potent, specific inhibitor of EPAC (exchange protein directly activated by cAMP). ESI-09 inhibits EPAC1 and EPAC2 with IC50 values of 3.2 and 1.4 μM, respectively, with no activity against PKA at 25 μM. In pancreatic cell lines, the compound blocks phosphorylation of Akt and insulin secretion. ESI-09 inhibits migration of pancreatic cancer cell lines.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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