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Merck
CN

SML0826

FH1

≥98% (HPLC)

Synonym(s):

BRD-K4477, N,N′-(Methylenedi-4,1-phenylene)bis-acetamide, N,N′-(Methylenedi-4,1-phenylene)diacetamide, NSC 12407

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About This Item

Empirical Formula (Hill Notation):
C17H18N2O2
CAS Number:
2719-05-3
Molecular Weight:
282.34
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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SMILES string

N(c1ccc(cc1)Cc2ccc(cc2)NC(=O)C)C(=O)C

InChI

1S/C17H18N2O2/c1-12(20)18-16-7-3-14(4-8-16)11-15-5-9-17(10-6-15)19-13(2)21/h3-10H,11H2,1-2H3,(H,18,20)(H,19,21)

InChI key

OEXMNSOPAKOPEF-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear (warmed)

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

FH1 (BRD-K4477) was found to enhance hepatocyte functions and promote the differentiation of induced pluripotent stem cell–derived hepatocytes toward a more mature phenotype than what had previouslybeen obtainable. Human induced pluripotent stem (iPS) cells that are differentiated toward hepatocyte-like (iHep) cells typically show an immature hepatic phenotype and have limited use as a renewable source of functional human hepatocytes. Cultures treated with both FH1 (BRD-K4477) and another compound that induces proliferation, FPH1 (BRD-6125), contained larger colonies of iHep cells, which showed more pronounced hepatocyte morphologies with a more mature phenotype than previously obtainable.
FH1 (BRD-K4477) was found to enhance hepatocyte functions and promote the differentiation of induced pluripotent stem cell–derived hepatocytes toward a more mature phenotype.

pictograms

Environment
GHS09

signalword

Warning

hcodes

H400

Hazard Classifications

Aquatic Acute 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000093056
0000093057
0000089150
026M4702V
093M4716V

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