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Merck
CN

SML0827

FPH1

≥98% (HPLC)

Synonym(s):

2-(N-(5-Chloro-2-methylphenyl)(methylsulfonamido)-N-(2,6-difluorophenyl)-acetamide, 2-[(5-Chloro-2-methylphenyl)(methylsulfonyl)amino]-N-(2,6-difluorophenyl)-acetamide, BRD-6125

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About This Item

Empirical Formula (Hill Notation):
C16H15ClF2N2O3S
CAS Number:
708219-39-0
Molecular Weight:
388.82
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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SMILES string

Fc1c(c(ccc1)F)NC(=O)CN([S](=O)(=O)C)c2c(ccc(c2)Cl)C

InChI

1S/C16H15ClF2N2O3S/c1-10-6-7-11(17)8-14(10)21(25(2,23)24)9-15(22)20-16-12(18)4-3-5-13(16)19/h3-8H,9H2,1-2H3,(H,20,22)

InChI key

WAOBCCBUTHNTFO-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

FPH1 (BRD-6125) induces functional proliferation of primary human hepatocytes in vitro.
FPH1 (BRD-6125) induces functional proliferation of primary human hepatocytes in vitro. Human induced pluripotent stem (iPS) cells can be differentiated toward hepatocyte-like (iHep) cells, but replication is not great, and cells typically show an immature hepatic phenotype and have limited use as a renewable source of functional human hepatocytes. FPH1 induced hepatocyte colonies were used in conjunction with FH1 (BRD-K4477) to induce a more mature phenotype. Cultures treated with both FH1 and FPH1 contained larger colonies of hepatocyte-like (iHep) cells, which showed more pronounced hepatocyte morphologies with a more mature phenotype than previously obtainable.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000494955
0000494955
0000391864
0000391864
0000097870

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