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Merck
CN

SML0828

FPH2

≥98% (HPLC)

Synonym(s):

4-(3-(5-Chloro-2-methoxyphenyl)thioxureido)-1-ethyl-1H-pyrazole-3-carboxamide, 4-[[[(5-Chloro-2-methoxyphenyl)amino]thioxomethyl]amino]-1-ethyl-1H-pyrazole-3-carboxamide, BRD-9424

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About This Item

Empirical Formula (Hill Notation):
C14H16ClN5O2S
CAS Number:
957485-64-2
Molecular Weight:
353.83
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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SMILES string

S=C(Nc2c[n](nc2C(=O)N)CC)Nc1c(ccc(c1)Cl)OC

InChI

1S/C14H16ClN5O2S/c1-3-20-7-10(12(19-20)13(16)21)18-14(23)17-9-6-8(15)4-5-11(9)22-2/h4-7H,3H2,1-2H3,(H2,16,21)(H2,17,18,23)

InChI key

PCHRYHSDDPPZBV-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

FPH2 (BRD-9424) induced functional proliferation of primary human hepatocytes in vitro.
FPH2 (BRD-9424) induced functional proliferation of primary human hepatocytes in vitro. Human induced pluripotent stem (iPS) cells can be differentiated toward hepatocyte-like (iHep) cells, but replication is not great, and cells typically show an immature hepatic phenotype and have limited use as a renewable source of functional human hepatocytes. FPH2 induced hepatocyte doublings at a rate consistent with reported liver regeneration kinetics. FPH2 can be used in conjunction with FH1 (BRD-K4477), which induces a more mature phenotype.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
093M4720V

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