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SML0849

GKA50

≥98% (HPLC)

Synonym(s):

6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylic acid

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About This Item

Empirical Formula (Hill Notation):
C26H28N2O6
CAS Number:
851884-87-2
Molecular Weight:
464.51
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 15 mg/mL, clear

storage temp.

−20°C

SMILES string

N(c3ncc(cc3)C(=O)O)C(=O)c1cc(cc(c1)O[C@H](Cc2ccccc2)C)O[C@H](COC)C

InChI

1S/C26H28N2O6/c1-17(11-19-7-5-4-6-8-19)33-22-12-21(13-23(14-22)34-18(2)16-32-3)25(29)28-24-10-9-20(15-27-24)26(30)31/h4-10,12-15,17-18H,11,16H2,1-3H3,(H,30,31)(H,27,28,29)/t17-,18-/m0/s1

InChI key

OCBMECSFDVUYQN-ROUUACIJSA-N

Biochem/physiol Actions

GKA50 is a specific activator of glucokinase (EC50 = 0.03 μM). In mouse MIN6 insulin-secreting cells and rat pancreatic islet cells, GKA50 elicits a leftward shift in response to sub-maximal glucose concentrations as measured by insulin secretion and elevation of intracellular calcium levels.
GKA50 is a specific activator of glucokinase.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H413

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 4

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000117775
0000117776
0000060251
0000060252
047M4612V

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Global Trade Item Number

SKUGTIN
SML0849-5MG04061833224076
SML0849-25MG04061833224069

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