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Merck
CN

SML0851

GZ-793A

≥98% (HPLC)

Synonym(s):

(R)-3-[2,6-cis-Di(4-methoxyphenethyl)piperidin-1-yl]propane-1,2-diol hydrochloride, 3-[(2R,6S)-2,6-Bis[2-(4-methoxyphenyl)ethyl]-1-piperidinyl]-(2R)-1,2-propanediol hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C26H37NO4 · HCl
CAS Number:
1356447-90-9
Molecular Weight:
464.04
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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SMILES string

Cl.N1([C@H](CCC[C@H]1CCc3ccc(cc3)OC)CCc2ccc(cc2)OC)C[C@@H](O)CO

InChI

1S/C26H37NO4.ClH/c1-30-25-14-8-20(9-15-25)6-12-22-4-3-5-23(27(22)18-24(29)19-28)13-7-21-10-16-26(31-2)17-11-21;/h8-11,14-17,22-24,28-29H,3-7,12-13,18-19H2,1-2H3;1H/t22-,23+,24-;/m1./s1

InChI key

FLFFCQKGCYZDOI-SJUVJREQSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 3 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

GZ-793A is a selective inhibitor of vesicular monoamine transporter 2 (VMAT2), which transports the monoamine neurotransmitters from cellular cytosol into synaptic vesicles. GZ-793A is 50-fold selective for VMAT over the serotonin or dopamine transporters. VMAT2 has recently been considered a target for the treatment of methamphetamine abuse. In rat studies, GZ-793A decreased self-administration of methamphetamine with no development of tolerance.
GZ-793A is a selective inhibitor of vesicular monoamine transporter 2 (VMAT2).

pictograms

Environment
GHS09

signalword

Warning

hcodes

H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000424700
0000424700
093M4626V

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Shunsuke Kimura et al.
PloS one, 16(1), e0245526-e0245526 (2021-01-20)
Neuroblastoma, the most common extracranial solid malignancy among children, originates from undifferentiated neural crest cells (NCC). Despite recent intensified treatment, high-risk patients still have a high mortality rate. To explore a new therapeutic strategy, we performed an integrated genomic and

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