SML0863
A-1070722
≥98% (HPLC)
Synonym(s):
1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
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About This Item
Empirical Formula (Hill Notation):
C17H13F3N4O2
CAS Number:
Molecular Weight:
362.31
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 15 mg/mL, clear
storage temp.
2-8°C
SMILES string
FC(F)(F)c1nc(ccc1)NC(=O)Nc2c3c(ncc2)cc(cc3)OC
InChI
1S/C17H13F3N4O2/c1-26-10-5-6-11-12(7-8-21-13(11)9-10)22-16(25)24-15-4-2-3-14(23-15)17(18,19)20/h2-9H,1H3,(H2,21,22,23,24,25)
InChI key
VQPBIJGXSXEOCU-UHFFFAOYSA-N
Biochem/physiol Actions
A-1070722 is a potent brain-penetrant inhibitor of glycogen synthase kinase-3 (GSK-3) α and β isoforms with a Ki of 0.6 nM for both GSK-3α and GSK-3β. A-1070722 showed > 50-fold selectivity for GSK-3 over a panel of other kinases tested, including CDK family members. A-1070722 decreased phosphorylation of microtubule-associated protein Tau and protected rat primary cortical neurons against β amyloid and glutamate challenge.
A-1070722 is a potent brain-penetrant inhibitor of glycogen synthase kinase-3 (GSK-3) α and β isoforms.
Features and Benefits
This compound is featured on the GSK-3 and PKB/Akt pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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