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Merck
CN

SML0874

GMQ hydrochloride

≥95% (HPLC)

Synonym(s):

2-Guanidine-4-methylquinazoline hydrochloride, 4-Methyl-2-guanidino quinazoline hydrochloride, N-(4-Methyl-2-quinazolinyl)-guanidine hydrochloride, NSC 403387 hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C10H11N5 · HCl
CAS Number:
5361-15-9
Molecular Weight:
237.69
MDL number:
MFCD00035249
UNSPSC Code:
12352200
PubChem Substance ID:
329825612
NACRES:
NA.77

Key Documents

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Quality Level

100

Assay

≥95% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

room temp

SMILES string

CC1=NC(NC(N)=N)=NC2=C1C=CC=C2.Cl

InChI

1S/C10H11N5.ClH/c1-6-7-4-2-3-5-8(7)14-10(13-6)15-9(11)12;/h2-5H,1H3,(H4,11,12,13,14,15);1H

InChI key

VNPZWQRWOHFAPD-UHFFFAOYSA-N

Biochem/physiol Actions

GMQ/2-Guanidine-4-methylquinazoline is a potent and selective modulator of acid-sensing ion channel (ASIC) that activates ASIC3 channels under neutral pH. GQM blocks acid-induced maximal peak current and alters ASICs pH dependence for activation and inactivation.
GMQ/2-guanidine-4-methylquinazoline is a potent and selective modulator of acid-sensing ion channel (ASIC).

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000080487
0000072530
0000027296
0000016671
126M4709V

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