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CN

SML0884

bpV(HOpic)

≥90% V basis

Synonym(s):

Bisperoxovanadium(HOpic), Dipotassium bisperoxo (5-hydroxypyridine-2-carboxyl) oxovanadate (V), K2[VO(O2)2C6H4NO3]

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About This Item

Empirical Formula (Hill Notation):
K2VOO2O2C6H4NO3
CAS Number:
722494-26-0
Molecular Weight:
347.24
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

bpV(HOpic), ≥90% V basis

SMILES string

[V]32(OO3)(OO2)([NH]1=CC(=O)CC=C1C(=O)[O-])[O-].[K+].[K+].O.O.O.O

InChI key

HSCJTESZNNRNPK-UHFFFAOYSA-M

InChI

1S/C6H5NO3.2K.2O2.4H2O.O.V/c8-4-1-2-5(6(9)10)7-3-4;;;2*1-2;;;;;;/h2-3H,1H2,(H,9,10);;;;;4*1H2;;/q;2*+1;2*-2;;;;;-1;+4/p-1

assay

≥90% V basis

form

powder

storage condition

desiccated
protect from light

color

faintly yellow to dark yellow

solubility

H2O: 20 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Related Categories

Application

bpV(HOpic) has been used in pharmacological perturbation of cell migration related signaling pathway.

Biochem/physiol Actions

bpV(OHpic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN, phosphatase and tensin homolog, a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(HOpic) are 14 nM for PTEN compared to 4.9 μM for PTPβ and 25.3 μM for PTP-1β. bpV(HOpic) has been shown to enhance PI3K/Akt signaling that could prevent myocardium from ischemia-reperfusion injury.
bpV(OHpic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN.

Other Notes

Soluble in DMSO or water. NOTE: The product is not stable in water. Decomposition starts immediately after solubilization. Rate of decomposition is slower in dry DMSO.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000392128
0000392128
0000405885
0000405885
0000218352

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Directed migration of cancer cells guided by the graded texture of the underlying matrix.
Park J, et al.
Nature Materials, 15(7), 792-792 (2016)
Thomas Theis et al.
Molecular neurobiology, 55(10), 8203-8215 (2018-03-10)
Glycosylation fine-tunes signal transduction of adhesion molecules during neural development and supports synaptic plasticity and repair after injury in the adult nervous system. One abundantly expressed neural glycan is LewisX (LeX). Although it is known that its expression starts at

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