SML0884
bpV(HOpic)
≥90% V basis
Synonym(s):
Bisperoxovanadium(HOpic), Dipotassium bisperoxo (5-hydroxypyridine-2-carboxyl) oxovanadate (V), K2[VO(O2)2C6H4NO3]
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About This Item
Empirical Formula (Hill Notation):
K2VOO2O2C6H4NO3
CAS Number:
Molecular Weight:
347.24
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥90% V basis
Form:
powder
Storage condition:
desiccated, protect from light
Quality Segment
assay
≥90% V basis
form
powder
storage condition
desiccated, protect from light
color
faintly yellow to dark yellow
solubility
H2O: 20 mg/mL, clear
storage temp.
−20°C
SMILES string
[V]32(OO3)(OO2)([NH]1=CC(=O)CC=C1C(=O)[O-])[O-].[K+].[K+].O.O.O.O
InChI
1S/C6H5NO3.2K.2O2.4H2O.O.V/c8-4-1-2-5(6(9)10)7-3-4;;;2*1-2;;;;;;/h2-3H,1H2,(H,9,10);;;;;4*1H2;;/q;2*+1;2*-2;;;;;-1;+4/p-1
InChI key
HSCJTESZNNRNPK-UHFFFAOYSA-M
Application
bpV(HOpic) has been used in pharmacological perturbation of cell migration related signaling pathway.
Biochem/physiol Actions
bpV(OHpic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN.
bpV(OHpic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN, phosphatase and tensin homolog, a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(HOpic) are 14 nM for PTEN compared to 4.9 μM for PTPβ and 25.3 μM for PTP-1β. bpV(HOpic) has been shown to enhance PI3K/Akt signaling that could prevent myocardium from ischemia-reperfusion injury.
Other Notes
Soluble in DMSO or water. NOTE: The product is not stable in water. Decomposition starts immediately after solubilization. Rate of decomposition is slower in dry DMSO.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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