SML0885
bpV(pic)
≥95% V basis
Synonym(s):
Dipotassium Bisperoxovanadium(pic) dihydrate, Dipotassium bisperoxo (picolinato) oxovanadate (V) dihydrate, K2 [VO(O2)2C6H4NO2] · 2 H2O
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About This Item
Empirical Formula (Hill Notation):
K2VOO2O2C6H4NO2 · 2H2O
CAS Number:
Molecular Weight:
367.27
NACRES:
NA.77
UNSPSC Code:
12352200
Quality Level
assay
≥95% V basis
form
powder
storage condition
protect from light
color
faintly yellow to dark yellow
solubility
H2O: 20 mg/mL, clear
storage temp.
−20°C
Application
bpV(pic) has been used in cell culture treatment to study the route of activation of multiple pathways required for HERV (human endogenous retroviruses) transcription.
Biochem/physiol Actions
bpV(pic) contains a polar side chain, and specifically inhibits PTEN(phosphatase and tensin homolog) unlike its parent compound, which targets several other phosphatases too. Thus, making bpV(pic) more a prefered inhibitor. bpV(pic) is recognized as a potent activator of multiple sclerosis (an autoimmune disorder) related human endogenous retroviruses.
bpV(pic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for phosphatase and tensin homolog (PTEN), a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(pic) are 31 nM for PTEN compared to 12.7 μM for PTPβ and 61 μM for PTP-1β. bpV(pic) can also act as an insulin mimetic and activate insulin receptor kinase (IRK).
bpV(pic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for phosphatase and tensin homolog (PTEN).
Other Notes
Light Sensitive
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Xiaodong Wu et al.
CNS neuroscience & therapeutics, 29(11), 3598-3611 (2023-06-13)
Neuronal abnormalities are closely associated with major depressive disorder (MDD). Available evidence suggests a role for microRNAs (miRNAs) in regulating the expression of genes involved in MDD. Hence, miRNAs that can be potential therapeutic targets need to be identified. A
Compound signaling activates endogenous retroviruses by inducing enhancer and gene-neighborhood transcription.
Azebi S, et al.
bioRxiv, 284695 (2018)
Phosphatase and tensin homologue deleted on chromosome ten (PTEN) as a molecular target in lung epithelial wound repair.
Lai J P, et al.
British Journal of Pharmacology, 152(8), 1172-1184 (2007)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML0885-25MG | 04061833444832 |
| SML0885-5MG | 04061833224229 |