SML0886
Leukadherin-1
≥98% (HPLC)
Synonym(s):
4-[5-[[4-Oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-benzoic acid, LA1, Leukadhedrin 1, Leukadherin 1
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About This Item
Empirical Formula (Hill Notation):
C22H15NO4S2
CAS Number:
Molecular Weight:
421.49
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
assay
≥98% (HPLC)
form
powder
color
, yellow to orange to brown
solubility
DMSO: 3 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
S1\C(=C/c3[o]c(cc3)c4ccc(cc4)C(=O)O)\C(=O)N(C1=S)Cc2ccccc2
InChI
1S/C22H15NO4S2/c24-20-19(29-22(28)23(20)13-14-4-2-1-3-5-14)12-17-10-11-18(27-17)15-6-8-16(9-7-15)21(25)26/h1-12H,13H2,(H,25,26)/b19-12-
InChI key
AEZGRQSLKVNPCI-UNOMPAQXSA-N
Biochem/physiol Actions
Leukadherin-1 is an agonist of complement receptor-3 (CR3) and exhibits anti-inflammatory activity. It is an allosteric agonist that activates integrin by binding to a different site from the ligand binding. Leukadherin-1 plays an important role in the margination and adhesion of neutrophils to the endothelial lining of the blood vessels.
Leukadherin-1 is an agonist of integrin CD11b/CD18
Leukadherin-1 is an agonist of integrin CD11b/CD18 that can increase the extent of CD11b/CD18-dependent cell adhesion of transfected cells and of primary human and mouse neutrophils. Also, Leukadherin-1 decreases leukocyte recruitment and reduced arterial narrowing after injury in rats.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Catherine M Dickinson et al.
Journal of intensive care, 6, 19-19 (2018-03-24)
Multi-organ failure occurs during critical illness and is mediated in part by destructive neutrophil-to-endothelial interactions. The β2 integrin receptor, CR3 (complement receptor 3; Mac-1; CD11b/CD18), which binds endothelial intercellular adhesion molecule-1 (ICAM-1), plays a key role in promoting the adhesion
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML0886-5MG | 04061833213452 |
| SML0886-25MG | 04061833213445 |