SML0889
bpV(phen)
≥95% V basis
Synonym(s):
Potassium bisperoxo(1,10-phenanthroline)oxovanadate (V) hydrate
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About This Item
Empirical Formula (Hill Notation):
KVO5C12H8N2 · xH2O
CAS Number:
Molecular Weight:
350.24 (anhydrous basis)
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% V basis
Form:
powder
Storage condition:
protect from light
Quality Segment
assay
≥95% V basis
form
powder
storage condition
protect from light
color
faintly yellow to dark yellow
solubility
H2O: 20 mg/mL, clear
storage temp.
−20°C
SMILES string
O=[V]123([N]4=CC=CC5=C4C6=C(C=CC=[N]62)C=C5)(OO3)OO1.[K]
InChI
1S/C12H8N2.K.2H2O2.O.V/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;;2*1-2;;/h1-8H;;2*1-2H;;/q;+1;;;;
InChI key
MQPXOTNOFVCXDA-UHFFFAOYSA-N
Biochem/physiol Actions
bpV(phen) (potassium bisperoxo(bipyridine)oxovanadate) shows protective effect against disease progression in leishmaniasis by mediating NO-dependent microbicidal action.
bpV(phen) is an insulin receptor kinase (IRK) activator and an inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN, phosphatase and tensin homolog, a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(phen) are 38 nM for PTEN compared to 343 nM for PTPβ and 920 nM for PTP-1β. bpV(phen) has anti-inflammatory effects in oxidative stress including inhibitory effects on oxidative stress-induced cardiomyocyte injury that may be partially modulated by the action of ROS on PTEN. It may also be involved in differentiation.
bpV(phen) is an insulin receptor kinase (IRK) activator and an inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN.
Other Notes
Light Sensitive
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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