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Merck
CN

SML0893

M8-B hydrochloride

≥98% (HPLC)

Synonym(s):

N-(2-Aminoethyl)-N-(4-(benzyloxy)-3-methoxybenzyl)thiophene-2-carboxamide hydrochloride, N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C22H24N2O3S · HCl
CAS Number:
883976-12-3
Molecular Weight:
432.96
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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SMILES string

[s]1c(ccc1)C(=O)N(CCN)Cc2cc(c(cc2)OCc3ccccc3)OC.Cl

InChI

1S/C22H24N2O3S.ClH/c1-26-20-14-18(9-10-19(20)27-16-17-6-3-2-4-7-17)15-24(12-11-23)22(25)21-8-5-13-28-21;/h2-10,13-14H,11-12,15-16,23H2,1H3;1H

InChI key

FMQJBHACRTZLME-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

Quality Level

100

Related Categories

Application

M8-B hydrochloride has been used as a transient receptor potential melastatin-8 (TRPM8) channel antagonist to study its therapeutic efficiency on a mouse model of severe dry eye disease (DED) induced by the excision of extra-orbital lacrimal and Harderian glands.

Biochem/physiol Actions

M8-B is a selective and potent antagonist of the transient receptor potential melastatin-8 (TRPM8) channel.
M8-B is a selective and potent antagonist of the transient receptor potential melastatin-8 (TRPM8) channel. M8-B blocked cold-induced and icilin or methol-induced activation of rat, human, and murine TRPM8 channels with IC50 values in rat ranging from 7.8 nM to 64.3 nM, and it did not block other TRP channels (IC50 values > 20 mM). M8-B decreased deep body temperature in both mice and rats, showing that blockade of TRPM8 receptor might be used to induce therapeutic hypothermia, an effective treatment in cardiac arrest.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000090237
0000057735
0000020034
123M4708V

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Darine Fakih et al.
International journal of molecular sciences, 21(22) (2020-11-25)
Dry eye disease (DED) is commonly associated with ocular surface inflammation and pain. In this study, we evaluated the effectiveness of repeated instillations of transient receptor potential melastatin 8 (TRPM8) ion channel antagonist M8-B on a mouse model of severe

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