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SML0898

Mps1-IN-3

≥98% (HPLC)

Synonym(s):

1-(4-(6-(2-(Isopropylsulfonyl)phenylamino)-9H-purin-2-ylamino)-3-methoxyphenyl)piperidin-4-ol

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About This Item

Empirical Formula (Hill Notation):
C26H31N7O4S
CAS Number:
1609584-72-6
Molecular Weight:
537.63
UNSPSC Code:
12352200
PubChem Substance ID:
329825614
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

light yellow to dark yellow

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC1CCN(C2=CC=C(NC3=NC(NC=N4)=C4C(NC5=C(S(=O)(C(C)C)=O)C=CC=C5)=N3)C(OC)=C2)CC1

InChI

1S/C26H31N7O4S/c1-16(2)38(35,36)22-7-5-4-6-20(22)29-25-23-24(28-15-27-23)31-26(32-25)30-19-9-8-17(14-21(19)37-3)33-12-10-18(34)11-13-33/h4-9,14-16,18,34H,10-13H2,1-3H3,(H3,27,28,29,30,31,32)

InChI key

OFRMASLPWOMYHN-UHFFFAOYSA-N

General description

Monopolar spindle 1 (Mps1) protein contains a TPR (tetratricopeptide repeat) motif at its N-terminal and a C-terminal kinase domain.

Application

Mps1-IN-3 has been used in 2D-proliferation and 3D-organotypic culture outgrowth assays.

Biochem/physiol Actions

Mps1 mediates phosphorylation of kinetochore scaffold 1.
Mps1-IN-3 is an inhibitor of Monopolar spindle 1 (MPS1, also known as TTK), a Dual-specificity kinase required for spindle pole body duplication and spindle checkpoint function. Mps1-IN-3 inhibited Mps1 kinase activity with an IC50 value of 50 nM inhibited the proliferation of U251 glioblastoma cells as determined by cell counting with an IC50 value of approximately 5 μM, and sensitized glioblastoma cells to vincristine in orthotopic mouse models.
Mps1-IN-3 is an inhibitor of Monopolar spindle 1 (MPS1.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
014M4723V

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Advances in Cancer Drug Targets: Volume: 2, 61-61 (2014)
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Morrison C D, et al.
Cell Death & Disease, 8(6), e2899-e2899 (2017)

Global Trade Item Number

SKUGTIN
SML0898-25MG04061832451190
SML0898-5MG04061832451206

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