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Merck
CN

SML0919

ML221

≥98% (HPLC)

Synonym(s):

5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one

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About This Item

Empirical Formula (Hill Notation):
C17H11N3O6S
CAS Number:
877636-42-5
Molecular Weight:
385.35
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Key Documents

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SMILES string

S(Cc2[o]cc([c](c2)=O)OC(=O)c3ccc(cc3)[N+](=O)[O-])c1ncccn1

InChI

1S/C17H11N3O6S/c21-14-8-13(10-27-17-18-6-1-7-19-17)25-9-15(14)26-16(22)11-2-4-12(5-3-11)20(23)24/h1-9H,10H2

InChI key

UASIRTUMPRQVFY-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

ML221 is an antagonist of the apelin receptor (also known as APJ).
ML221 is an antagonist of the apelin receptor (also known as APJ). ML221 blocks Apelin-13 mediated receptor activation (recruitment of β-arrestin) with an IC50 of 1.75 μM.
ML221 is capable of suppressing the cultured-endothelial cell proliferation. In oxygen-induced retinopathy (OIR) mice model, ML221 can block the pathological angiogenesis and increase the recovery of normal vessels into the ischemic regions in the retina. It can also inhibit the formation of neovascular tufts.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000242236
0000242237
0000242237
0000242236
0000054910

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An apelin receptor antagonist prevents pathological retinal angiogenesis with ischemic retinopathy in mice
Ishimaru Y, et al.
Scientific reports, 7(15062), 1-9 (2017)

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