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Merck
CN

SML0931

Carbimazole

≥98% (HPLC)

Synonym(s):

1-Ethoxycarbonyl-3-methyl-2-thio-4-imidazoline, 1-Methyl-3-carbethoxy-2-thioglyoxalone, 2,3-Dihydro-3-methyl-2-thioxo-1H-imidazole-1-carboxylic acid ethyl ester, Athyromazole, Carbethoxymethimazole, Carbimazol, Ethyl 3-methyl-2-thioimidazoline-1-carboxylate

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About This Item

Empirical Formula (Hill Notation):
C7H10N2O2S
CAS Number:
22232-54-8
Molecular Weight:
186.23
UNSPSC Code:
12352200
EC Number:
244-854-4
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Key Documents

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Product Name

Carbimazole, ≥98% (HPLC)

SMILES string

S=[c]1[n](cc[n]1C(=O)OCC)C

InChI key

CFOYWRHIYXMDOT-UHFFFAOYSA-N

InChI

1S/C7H10N2O2S/c1-3-11-7(10)9-5-4-8(2)6(9)12/h4-5H,3H2,1-2H3

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Carbimazole is a pro-drug of methimazole that is an inhibitor of thyroid enzyme thyroperoxidase.
Carbimazole is a pro-drug of methimazole that is an inhibitor of thyroid enzyme thyroperoxidase. Carbimazole is used to treat hyperthyroidism. Also, carbimazole induces phosphorylation of eukaryotic elongation factor eEF2.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000487877
0000487879
0000487879
0000487877
0000218151

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Adoree Yi Ying Lim et al.
Singapore medical journal, 54(7), e133-e136 (2013-08-01)
A 24-year-old Chinese woman with Graves' disease presented with myositis two months after treatment with carbimazole. The patient's myositis resolved with hydration and cessation of carbimazole. No other causes of myositis were found, and a change in the medication to
Franz Ludwig Dumoulin et al.
BMJ case reports, 2012, doi:10-doi:10 (2012-05-19)
A middle aged woman, previously healthy with the exception of mild seasonal asthma was presented with signs of acute hepatitis. The further investigation showed acute hepatitis E virus infection associated with autoimmune thyroiditis. Treatment was started with propranolol and carbimazol
Iodinated contrast-induced thyrotoxicosis.
Paul Dunne et al.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 185(2), 144-147 (2012-11-14)
E T Bell et al.
The Journal of small animal practice, 53(11), 661-663 (2012-09-11)
A 12-year-old female neutered ragdoll crossbred cat was presented for investigation of generalised weakness and regurgitation. The cat was being treated with transdermal methimazole for hyper-thyroidism, which had been diagnosed 10 weeks previously. An acetylcholine receptor antibody titre was consistent
Dhanya Muralidharan et al.
Oral surgery, oral medicine, oral pathology and oral radiology, 115(5), 617-623 (2013-03-05)
Animal studies have shown thyroid dysfunction affects salivary gland functioning, however conclusive human studies are lacking. We sought to assess the qualitative and quantitative changes in saliva among subjects with thyroid dysfunction prior to and following treatment. A longitudinal observational
View All Related Papers

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