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SML0947

YN1

≥98% (HPLC)

别名:

7,8-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

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关于此项目

经验公式（希尔记法）:
C15H10O5
化学文摘社编号:
75187-63-2
分子量:
270.24
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

[o]1c2c([c](c(c1)c3ccc(cc3)O)=O)ccc(c2O)O

InChI

1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-15-10(13(11)18)5-6-12(17)14(15)19/h1-7,16-17,19H

InChI key

BMZFZTMWBCFKSS-UHFFFAOYSA-N

Biochem/physiol Actions

YN1 is a potent inhibitor of PFKFB3.
YN1 is a potent inhibitor of PFKFB3 (6-Phosphfructo-2-kinase/fructose-2,6-bisphosphatase: IC50 = 670 nM). PFKFB3 is over expressed in many cancers, and catalyzes the production of fructose-2,6-bisphosphate, which can potentiate PFK1 activity, enhancing glycolysis in tumor cells. YN1 inhibits glycolysis and proliferation in HeLa cells.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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