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Merck
CN

SML1002

Sigma-Aldrich

Sinomenine hydrochloride

≥98% (HPLC)

Synonym(s):

(9a,13a,14a)-7,8-Didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-morphinan-6-one hydrochloride, Cucoline hydrochloride, Kukolin hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C19H23NO4 · HCl
CAS Number:
6080-33-7
Molecular Weight:
365.85
MDL number:
MFCD01714307
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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biological source

plant (Sinomenium acutum)

Assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -70 to -90°, c = 1 in H2O

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

color

white to beige

solubility

H2O: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC1=C(OC)C=CC(C2)=C1[C@]3(CC(C(OC)=C4)=O)[C@@]4([H])[C@H]2N(C)CC3.Cl

InChI

1S/C19H23NO4.ClH/c1-20-7-6-19-10-14(21)16(24-3)9-12(19)13(20)8-11-4-5-15(23-2)18(22)17(11)19;/h4-5,9,12-13,22H,6-8,10H2,1-3H3;1H/t12-,13+,19-;/m1./s1

InChI key

YMEVIMJAUHZFMW-VUIDNZEBSA-N

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Biochem/physiol Actions

Sinomenine is a herbal medicine used to treat inflammatory diseases like rheumatoid arthritis. Sinomenine had anti-inflammatory effects in several animal models of inflammation, and inhibits mast cell degranulation and histamine release. Additionally, Sinomenine potentiates renewal of human embryonic stem cells.
Sinomenine is a herbal medicine used to treat inflammatory diseases.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000406423
0000406423
0000143819
0000039492
044M4759V

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Yuting Xu et al.
Artificial cells, nanomedicine, and biotechnology, 47(1), 4131-4138 (2019-11-09)
Background: Accumulating evidence displays that sinomenine hydrochloride (SH) are utilised to treat a variety of cancers. Nevertheless, the influences of SH on ovarian cancer stay blurry. We endeavoured to uncover the antitumor effects of SH on ovarian cancer and underlying

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