SML1009
PFK15
≥98% (HPLC)
Synonym(s):
1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one
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Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
n1ccc(cc1)C(=O)\C=C\c2nc3c(cc2)cccc3
InChI
1S/C17H12N2O/c20-17(14-9-11-18-12-10-14)8-7-15-6-5-13-3-1-2-4-16(13)19-15/h1-12H/b8-7+
InChI key
UJJUKZPBUMCSJZ-BQYQJAHWSA-N
Application
PFK15, a PFKFB3 inhibitor has been used to investigate its effects on the modulation of autophagy and proliferation in rhabdomyosarcoma (RD) cells.
Biochem/physiol Actions
PFK15 is also referred as 1-(4-pyridinyl)-3-(2-quinolinyl)-2-propen-1-one. It prevents autophagy and multiplication in rhabdomyosarcoma cells. PFK15 results in cell death in gastric cancer cells via mitochondrial pathway. It also blocks MKN45 (human gastric cancer cell lines) tumor growth in vivo. PFK15 promotes cell cycle arrest and changes the upregulation of key cell cycle proteins.
PFK15 is potent and selective antagonist of PFKB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3) that causes a rapid induction of apoptosis in cancer and transformed cells. PFK15 inhibits the growth of LLC xenografts.
PFK15 is potent and selective antagonist of PFKB3.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Articles
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
PFK15, a PFKFB3 antagonist, inhibits autophagy and proliferation in rhabdomyosarcoma cells.
Wang C, et al.
International Journal of Molecular Medicine, 42(1), 359-367 (2018)
PFK15, a small molecule inhibitor of PFKFB3, induces cell cycle arrest, apoptosis and inhibits invasion in gastric cancer.
Zhu W, et al.
PLoS ONE, 11(9), e0163768-e0163768 (2016)
Lingyan Jiang et al.
Nature communications, 12(1), 879-879 (2021-02-11)
Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on serine synthesis are mediated by
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML1009-25MG | 04061832724386 |
| SML1009-5MG | 04061832724393 |