SML1011
INDY
≥98% (HPLC)
Synonym(s):
(1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone
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About This Item
Empirical Formula (Hill Notation):
C12H13NO2S
CAS Number:
Molecular Weight:
235.30
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
S1c2c(cc(cc2)O)N(\C\1=C/C(=O)C)CC
InChI
1S/C12H13NO2S/c1-3-13-10-7-9(15)4-5-11(10)16-12(13)6-8(2)14/h4-7,15H,3H2,1-2H3/b12-6+
InChI key
GCSZJMUFYOAHFY-WUXMJOGZSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
−20°C
Quality Level
Related Categories
Biochem/physiol Actions
INDY is a potent inhibitor of Dyrk1A and Dyrk1B (dual-specificity tyrosine-phosphorylation-regulated kinase 1). The IC50 values for inhibition of Dyrk1A and 1B are 240 and 230 nM, respectively. INDY impairs the self-renewal capacity of neural stem cells and glioblastoma tumor-initiating cells.
INDY is a potent inhibitor of Dyrk1A and Dyrk1B.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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