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SML1011

INDY

≥98% (HPLC)

Synonym(s):

(1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone

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About This Item

Empirical Formula (Hill Notation):
C12H13NO2S
CAS Number:
1169755-45-6
Molecular Weight:
235.30
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

−20°C

SMILES string

S1c2c(cc(cc2)O)N(\C\1=C/C(=O)C)CC

InChI

1S/C12H13NO2S/c1-3-13-10-7-9(15)4-5-11(10)16-12(13)6-8(2)14/h4-7,15H,3H2,1-2H3/b12-6+

InChI key

GCSZJMUFYOAHFY-WUXMJOGZSA-N

Biochem/physiol Actions

INDY is a potent inhibitor of Dyrk1A and Dyrk1B (dual-specificity tyrosine-phosphorylation-regulated kinase 1). The IC50 values for inhibition of Dyrk1A and 1B are 240 and 230 nM, respectively. INDY impairs the self-renewal capacity of neural stem cells and glioblastoma tumor-initiating cells.
INDY is a potent inhibitor of Dyrk1A and Dyrk1B.

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Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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