SML1014
CYM-5520
≥98% (HPLC)
Synonym(s):
1-[2-(1-Benzyl-2,5-dimethyl-1H-pyrrol-3-yl)-2-oxo-ethyl]-6-oxo-1,6-dihydro-pyridine-3-carbonitrile
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About This Item
Empirical Formula (Hill Notation):
C21H19N3O2
CAS Number:
Molecular Weight:
345.39
NACRES:
NA.77
UNSPSC Code:
12352211
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
Application
CYM-5520 has been used as a sphingosine 1-phosphate receptor 2 (S1pr2) agonist in pancreatic adenocarcinoma cell line (CFPAC-1).
Biochem/physiol Actions
CYM-5520 mediates phosphorylation of transcription factor p65. It upregulates trabecular number, thickness as well as tibial bone volume density in osteoblasts.
CYM-5520 is a specific, noncompetitive allosteric agonist of sphingosine 1-phosphate receptor 2 (S1PR2; EC50 = 1.0 μM). The compound CYM-5520 does not show any agonsit activity towards S1PR1, S1PR3, S1PR4 or S1PR5.
CYM-5520 is a specific, noncompetitive allosteric agonist of sphingosine 1-phosphate receptor 2.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Filamin A expression negatively regulates sphingosine-1-phosphate-induced NF-kappaB activation in melanoma cells by inhibition of Akt signaling
Campos LS, et al.
Molecular and Cellular Biology, 36(2), 320-329 (2016)
Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts
Higashi K, et al.
Bone, 93, 1-11 (2016)
p120 catenin suppresses basal epithelial cell extrusion in invasive pancreatic neoplasia
Hendley AM, et al.
Cancer Research, 76(11), 3351-3363 (2016)
Articles
Discover Bioactive Small Molecules for Lipid Signaling Research
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML1014-25MG | 04061833224625 |
| SML1014-5MG | 04061833224632 |
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