SML1033
A-278637
≥98%
Synonym(s):
(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydro-thieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide
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About This Item
Empirical Formula (Hill Notation):
C17H15BrFNO3S
CAS Number:
Molecular Weight:
412.27
NACRES:
NA.77
UNSPSC Code:
12352202
assay
≥98%
form
powder
optical activity
[α]/D -44 to -54°, c = 0.1 in acetonitrile
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
A-278637 is a selective opener of ATP-sensitive K (KATP) channels (EC50 = 102 nM) that blocks contraction of bladder smooth muscle in both in vivo and in vitro assays. A-278637 is 15-fold more selective than nifedipine for bladder compared other smooth muscle KATP channels, and displays reduced effects on mean arterial pressure compared to other channel openers.
A-278637 is a selective opener of ATP-sensitive K (KATP) channels.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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