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Merck
CN

SML1039

ENMD-1068 hydrochloride

≥97% (HPLC)

Synonym(s):

6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C15H29N3O2 · HCl
CAS Number:
789488-77-3
Molecular Weight:
319.87
UNSPSC Code:
51111800
NACRES:
NA.77

Key Documents

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SMILES string

N1(CCN(CC1)C(=O)CCCCCN)C(=O)CC(C)C

InChI

1S/C15H29N3O2/c1-13(2)12-15(20)18-10-8-17(9-11-18)14(19)6-4-3-5-7-16/h13H,3-12,16H2,1-2H3

InChI key

VRZYMMVEALDDBH-UHFFFAOYSA-N

assay

≥97% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 25 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Application

ENMD-1068 hydrochloride has been used as a protease-activated receptor 2 (PAR2) antagonist to determine the pathway responsible for paw edema induced by Crotalus durissus terrificus venom serine protease (Cdtsp 2).

Biochem/physiol Actions

ENMD-1068 hydrochloride exhibits anti-angiogenic and anti-inflammatory activities.
ENMD-1068 is an antagonist of protease-activated receptor 2 (PAR2).
ENMD-1068 is an antagonist of protease-activated receptor 2 (PAR2). The compound blocks TNFα production in synovial explants from patients with arthritis, and inhibits mast cell tryptase-induced recruitment of eosinophils into the pleural cavity of mice.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000510349
0000510347
0000510347
0000510349
0000354550

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Caroline R C Costa et al.
International journal of molecular sciences, 19(8) (2018-08-17)
Snake venom serine proteases (SVSPs) represent an essential group of enzymatic toxins involved in several pathophysiological effects on blood homeostasis. Some findings suggest the involvement of this class of enzymatic toxins in inflammation. In this paper, we purified and isolated
Yifeng Wang et al.
American journal of obstetrics and gynecology, 210(6), 531-531 (2014-02-06)
Protease-activated receptor 2 plays an important role in the pathogenesis of endometriosis. We studied the effect of ENMD-1068, a protease-activated receptor 2 antagonist, on the development of endometriosis in a noninvasive fluorescent mouse model. A red fluorescent protein-expressing xenograft model

Articles

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