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Merck
CN

SML1052

2-D08

≥98% (HPLC)

Synonym(s):

2′,3′,4′-trihydroxy-flavone, 2-(2,3,4-Trihydroxyphenyl)-4H-1-Benzopyran-4-one

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About This Item

Empirical Formula (Hill Notation):
C15H10O5
CAS Number:
144707-18-6
Molecular Weight:
270.24
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

2-D08, ≥98% (HPLC)

SMILES string

[o]1c2c([c](cc1c3c(c(c(cc3)O)O)O)=O)cccc2

InChI key

JJAXTFSPCLZPIW-UHFFFAOYSA-N

InChI

1S/C15H10O5/c16-10-6-5-9(14(18)15(10)19)13-7-11(17)8-3-1-2-4-12(8)20-13/h1-7,16,18-19H

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Related Categories

Application

2-D08 has been used as a small ubiquitin-like modifier (SUMO)ylation inhibitor.

Biochem/physiol Actions

2-D08 is a potent and cell-permeable inhibitor of sumoylation that block the transfer of SUMO (small ubiquitin-like modifier) from the E2 enzyme (Ubc9) thioester conjugate to the substrate.
2-D08 is a potent and cell-permeable inhibitor of sumoylation.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000187653
0000187654
0000187654
0000187653
0000091194

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MG132?induced progerin clearance is mediated by autophagy activation and splicing regulation.
Harhouri K, et al.
EMBO Molecular Medicine (2017)
RAS GTPases are modified by SUMOylation.
Choi B H, et al.
Oncotarget, 9(4), 4440-4440 (2018)
Byeong Hyeok Choi et al.
Oncotarget, 9(4), 4440-4450 (2018-02-13)
RAS proteins are GTPases that participate in multiple signal cascades, regulating crucial cellular processes including cell survival, proliferation, differentiation, and autophagy. Mutations or deregulated activities of RAS are frequently the driving force for oncogenic transformation and tumorigenesis. Given the important
Pan Zhou et al.
Biochemical and biophysical research communications, 513(4), 1063-1069 (2019-04-24)
Acute myeloid leukemia (AML) is a heterogeneous clonal hematopoietic malignancy with poor survival and frequent relapse. Recently, a posttranslational modification of proteins with small ubiquitin-like modifiers (SUMO) has been notably implicated in a wide spectrum of diseases, especially cancers. Ubc9
Karim Harhouri et al.
EMBO molecular medicine, 9(9), 1294-1313 (2017-07-05)
Hutchinson-Gilford progeria syndrome (HGPS) is a lethal premature and accelerated aging disease caused by a de novo point mutation in LMNA encoding A-type lamins. Progerin, a truncated and toxic prelamin A issued from aberrant splicing, accumulates in HGPS cells' nuclei
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