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SML1058

PBIT

≥98% (HPLC)

Synonym(s):

2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one; 2-(4-Methylphenyl)-2,3-dihydrobenzisothiazol-3-one, 2-p-Tolyl-1,2-benzisothiazolin-3-one

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About This Item

Empirical Formula (Hill Notation):
C14H11NOS
CAS Number:
2514-30-9
Molecular Weight:
241.31
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

[s]1[n]([c](c3c1cccc3)=O)c2ccc(cc2)C

InChI

1S/C14H11NOS/c1-10-6-8-11(9-7-10)15-14(16)12-4-2-3-5-13(12)17-15/h2-9H,1H3

InChI key

KRXMYBAZKJBJAB-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

S,S′-1,4-phenylenebis(1,2-ethanediyl)bis-isothiourea (PBIT) is an iNOS (inducible nitric oxide synthase) inhibito. It is capable of inhibiting the multiplication of breast cancer cell lines expressing high levels of JARIDB1.
PBIT is a potent inhibitor of JARID1B (KDM5B) histone lysine demethylase that inhibits removal of H3K4me3 in UACC-812 cells. PBIT inhibits proliferation of cells overexpressing JARID1B. PBIT is selective for JARID1 enzymes and does not inhibit demethylases UTX or JMJD3.
PBIT is a potent inhibitor of JARID1B (KDM5B).

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000206762
0000206762
0000029753
0000025322
054M4622V

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Melanomas: New Insights for the Healthcare Professional (2013)
The Inhibitor Index (2017)
Tharcisio Citrangulo Tortelli et al.
Aging, 13(18), 21914-21940 (2021-09-17)
Metformin has been tested as an anti-cancer therapy with potential to improve conventional chemotherapy. However, in some cases, metformin fails to sensitize tumors to chemotherapy. Here we test if the presence of P53 could predict the activity of metformin as

Articles

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Global Trade Item Number

SKUGTIN
SML1058-25MG04061832635897
SML1058-5MG04061832635903

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