SML1064
IMM-01
≥98% (HPLC)
Synonym(s):
2-[(2,4-Dihydroxyphenyl)methylene]-N-(1,1-dimethylethyl)-hydrazinecarbothioamide, Intramimic-01, N1-(tert-Butyl)-2-(2,4-dihydroxybenzylidene)hydrazine-1-carbothioamide
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About This Item
Empirical Formula (Hill Notation):
C12H17N3O2S
CAS Number:
Molecular Weight:
267.35
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to light brown
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
S=C(N\N=C\c1c(cc(cc1)O)O)NC(C)(C)C
InChI
1S/C12H17N3O2S/c1-12(2,3)14-11(18)15-13-7-8-4-5-9(16)6-10(8)17/h4-7,16-17H,1-3H3,(H2,14,15,18)/b13-7+
InChI key
LTFUAYRGVLQXKC-NTUHNPAUSA-N
Application
IMM-01 has been used as a formin activator to study its effects on motor neurons (MNs).
Biochem/physiol Actions
IMM-01 binds and activates formin thereby leading to autoinhinition.
IMM-01 is an agonist of the mammalian Diaphanous (mDia)-related formins that triggers actin assembly and microtubule stabilization, serum response factor-mediated gene expression, cell-cycle arrest, and apoptosis. IMM-01 inhibits DID–DAD binding, which in turn activates mDia family of formins in cells. IMM-01 slows tumor growth in a mouse xenograft model of colon cancer.
IMM-01 is an agonist of the mammalian Diaphanous (mDia)-related formins that triggers actin assembly.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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