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Merck
CN

SML1095

PKI-166

≥98% (HPLC)

Synonym(s):

(R)-4-[4-[(1-Phenylethyl)amino]-1H-pyrrolo[2,3-d]pyrimidin-6-yl]-phenol, (R)-6-(4-Hydroxyphenyl)-4-[(1-phenylethyl)amino]-7H-pyrrolo[2,3-d]pyrimidine, 4-[4-(((R)-1-Phenylethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenol, 4-[4-[[(1R)-1-Phenylethyl]amino]-1H-pyrrolo[2,3-d]pyrimidin-6-yl]-phenol (9CI), CID 6918403, PKI 166, PKI166

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About This Item

Empirical Formula (Hill Notation):
C20H18N4O
CAS Number:
187724-61-4
Molecular Weight:
330.38
NACRES:
NA.77
PubChem Substance ID:
329825472
UNSPSC Code:
12352200
MDL number:
MFCD09970842

Key Documents

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Product Name

PKI-166, ≥98% (HPLC)

InChI

1S/C20H18N4O/c1-13(14-5-3-2-4-6-14)23-19-17-11-18(24-20(17)22-12-21-19)15-7-9-16(25)10-8-15/h2-13,25H,1H3,(H2,21,22,23,24)/t13-/m1/s1

SMILES string

OC(C=C1)=CC=C1C2=CC3=C(N2)N=CN=C3N[C@H](C)C4=CC=CC=C4

InChI key

XRYJULCDUUATMC-CYBMUJFWSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... EGFR(1956)

Related Categories

Biochem/physiol Actions

PKI-166 is a potent, selective and orally available EGF-R tyrosine kinase inhibitor.
PKI-166 is a potent, selective and orally available EGF-R tyrosine kinase inhibitor. PKI-166 potently inhibits the growth and metastasis of many human cancers including human pancreatic cancer.

Other Notes

Light and air sensitive.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000437268
0000437268
0000136919
074M4622V

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