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SML1101

Nedocromil sodium

≥98% (HPLC)

Synonym(s):

9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid sodium salt, Nedocromil disodium salt

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About This Item

Empirical Formula (Hill Notation):
C19H15NO7 · 2 Na
CAS Number:
69049-74-7
Molecular Weight:
415.30
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated
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Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

, white to beige to brown

solubility

H2O: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

[Na+].[Na+].[n]1(c2c([c](cc1C(=O)[O-])=O)cc3c([o]c(c[c]3=O)C(=O)[O-])c2CCC)CC

InChI

1S/C19H17NO7.2Na/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11;;/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26);;/q;2*+1/p-2

InChI key

JQEKDNLKIVGXAU-UHFFFAOYSA-L

Biochem/physiol Actions

Nedocromil is considered to be more effective in treating asthma compared to a placebo.
Nedocromil is a mast cell stabilizer and anti-inflammatory and anti-allergic drug.
Nedocromil is a mast cell stabilizer and anti-inflammatory and anti-allergic drug. Nedocromil inhibits the degranulation of mast cells, and prevents the activation of and mediator release from a variety of inflammatory cell types. Nedocromil inhibits release of histamine, leukotriene C4, and prostaglandin D2, but has no antihistamine, bronchodilator, or corticosteroid activity itself.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000532019
0000532019
0000413837
0000413837
0000186657

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Is nedocromil sodium effective treatment for asthma?
O'Byrne P M and Cook D
The European Respiratory Journal, 6(1), 5-6 (1993)
Ajantha Sinniah et al.
International immunopharmacology, 32, 87-95 (2016-01-25)
1.We investigated the role of Annexin (ANX)-A1 and its receptor, ALX/FPR2, in the regulation of mast cell degranulation produced by compound 48/80. 2.Both human cord-blood derived mast cells (CBDMCs) and murine bone marrow derived mast cells (BMDMCs) release phosphorylated ANX-A1

Global Trade Item Number

SKUGTIN
SML1101-50MG04061832636023
SML1101-10MG04061832636016

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