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SML1132

Pep2-8 trifluoroacetate salt

Name: Pep2-8 trifluoroacetate salt
Brand: SIGMA

≥95% (HPLC), powder

Synonym(s):

Ac-TVFTSWEEYLDWV-NH₂ trifluoroacetate salt, Ac-TVFTSWEEYLDWV-amide trifluoroacetate salt, Ac-Thr-Val-Phe-Thr-Ser-Trp-Glu-Glu-Tyr-Leu-Asp-Trp-Val-NH₂ trifluoroacetate salt

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About This Item

Empirical Formula (Hill Notation):

C₈₃H₁₁₀N₁₆O₂₄ · xC₂HF₃O₂

Molecular Weight:

1715.85 (free base basis)

NACRES:

NA.77

UNSPSC Code:

12352200

Assay:

≥95% (HPLC)

Form:

powder

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Properties

Quality Segment

100

assay

≥95% (HPLC)

form

powder

color

colorless to pale yellow

shipped in

wet ice

storage temp.

−20°C

Description

Biochem/physiol Actions

Pep2-8, a good mimic of epidermal growth factor precursor homology domain A (EGF-A), serves as a competitive inhibitor of low-density lipoprotein (LDL) receptor binding. It can be used as an anchor peptide in phage-display experiments to bind an extension peptide library to the groove site.

Pep2-8 is a potent PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor that selectively binds to PCSK9 and interferes with LDL receptor binding to PCSK9. Pep2-8 restores LDL receptor function and LDL uptake of PCSK9-treated HepG2 cells.

Pep2-8 is a potent PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor.

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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