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Merck
CN

SML1148

YIL-781 hydrochloride

≥98% (HPLC)

Synonym(s):

6-(4-Fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C24H28FN3O2 · xHCl
CAS Number:
875258-85-8
Molecular Weight:
409.50 (free base basis)
NACRES:
NA.77
PubChem Substance ID:
329825682
UNSPSC Code:
51111800
MDL number:
MFCD19690924

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InChI

1S/C24H28FN3O2.ClH/c1-16(2)27-12-4-5-18(14-27)15-28-17(3)26-23-11-10-21(13-22(23)24(28)29)30-20-8-6-19(25)7-9-20;/h6-11,13,16,18H,4-5,12,14-15H2,1-3H3;1H/t18-;/m0./s1

SMILES string

CC(C)N(CCC1)C[C@H]1CN(C(C)=N2)C(C3=C2C=CC(OC4=CC=C(F)C=C4)=C3)=O.Cl

InChI key

QQGRMONBDBMLSP-FERBBOLQSA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

, white to yellow to light brown

solubility

H2O: 2 mg/mL, clear (warmed)

storage temp.

room temp

Quality Level

100

Application

YIL-781 has been used as a ghrelin receptor (GHSR) antagonist in combination with methanandamide (mAEA) to study its effect on gastric vagal afferent mechanosensitivity.

Biochem/physiol Actions

YIL-781 is a Ghrelin receptor antagonist.
YIL-781 is a potent antagonist (Ki = 17 nM) of the growth hormone secretagogue receptor (GHS-R1). YIL-781 blocks ghrelin-induced reduction of insulin secretion in rat islets. In vivo, the compound YIL-781 improves glucose tolerance and reduces weight gain.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000029584
0000029583
104M4703V

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