SML1157
Eact
≥98% (HPLC)
Synonym(s):
3,4,5-Trimethoxy-N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)-benzamide
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About This Item
Empirical Formula (Hill Notation):
C22H24N2O5S
CAS Number:
Molecular Weight:
428.50
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C22H24N2O5S/c1-26-11-10-24(22-23-17(14-30-22)15-8-6-5-7-9-15)21(25)16-12-18(27-2)20(29-4)19(13-16)28-3/h5-9,12-14H,10-11H2,1-4H3
SMILES string
O=C(C1=CC(OC)=C(OC)C(OC)=C1)N(CCOC)C2=NC(C3=CC=CC=C3)=CS2
InChI key
ZUXNHFFVQWADJL-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Eact activates the Calcium-activated Chloride channel (CaCC) TMEM16A CaCC.
Eact activates the Calcium-activated Chloride channel (CaCC) TMEM16A CaCC. Eact stimulates CaCC conductance in salivary gland cells and submucosal airway epithelial cells. The compound Eact also stimulates submucosal gland secretion in human bronchial tissue and smooth muscle contraction in mouse intestine.
In rat arterial myocytes, Eact [3,4,5-trimethoxy-N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)benzamide] helps to activate chloride current and prevents estradiol synthesis in cultured mouse granulosa cells. It is a small molecule activator of TMEM16A (transmembrane member 16A), that activates TRPV1 (transient receptor potential cation channel subfamily V member 1) and generates pain and itch related symptoms. Eact also initiates endogenous TRPV1 expressed by DRG (dorsal root ganglion) neurons.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain?and itch?related behaviours.
Liu S, et al.
British Journal of Pharmacology, 173(7), 1208-1218 (2016)
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